Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memory

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dc.creatorCosta, Adeliane Castro da
dc.creatorNogueira, Sarah Veloso
dc.creatorKipnis, André
dc.creatorJunqueira-Kipnis, Ana Paula
dc.date.accessioned2018-11-07T09:55:04Z
dc.date.available2018-11-07T09:55:04Z
dc.date.issued2014-04-07
dc.description.abstractBacille Calmette–Guérin (BCG), an attenuated vaccine derived from Mycobacterium bovis, is the current vaccine of choice against tuberculosis (TB). Despite its protection against activeTB in children, BCG has failed to protect adults againstTB infection and active disease development, especially in developing countries where the disease is endemic. Currently, there is a significant effort toward the development of a newTB vaccine.This review article aims to address publications on recombinant BCG (rBCG) published in the last 5 years, to highlight the strategies used to develop rBCG, with a focus on the criteria used to improve immunological memory and protection compared with BCG. The literature review was done in April 2013, using the key words TB, rBCG vaccine, and memory. This review discusses the BCG strains and strategies currently used for the modification of BCG, including: overexpression of Mycobacterium tuberculosis (Mtb) immunodominant antigens already present in BCG; gene insertion of immunodominant antigens from Mtb absent in the BCG vaccine; combination of introduction and overexpression of genes that are lost during the attenuation process of BCG; BCG modifications for the induction of CD8CT-cell immune responses and cytokines expressing rBCG. Among the vaccines discussed,VPM1002, also called rBCGDureC:hly, is currently in human clinical trials. Much progress has been made in the effort to improve BCG, with some promising candidates, but considerable work is still required to address functional long-lasting memory.pt_BR
dc.identifier.citationCOSTA, Adeliane Castro da; NOGUEIRA, Sarah Veloso; KIPNIS, André; JUNQUEIRA-KIPNIS, Ana Paula. Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memory. Frontiers in Immunology, Lausanne, v. 5, p. 1-9, 2014.pt_BR
dc.identifier.doi10.3389/fimmu.2014.00152
dc.identifier.issne- 1664-3224
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16382
dc.language.isoengpt_BR
dc.publisher.countrySuicapt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectrBCGpt_BR
dc.subjectTuberculosispt_BR
dc.subjectVaccinept_BR
dc.subjectProtectionpt_BR
dc.subjectLong-term memorypt_BR
dc.subjectStrain differencespt_BR
dc.titleRecombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memorypt_BR
dc.typeArtigopt_BR

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