Asymptomatic oral cariage of Candida species in HIV -infected patients in the highly active antiretroviral therapy era
Data
2006-10
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Resumo
Oropharyngeal candidiasis is the most common opportunistic fungal infection in individuals infected with human
immunodeficiency virus. CD4 + lymphocytes count and the quantification of viral RNA in blood plasma have been found to be the
main markers of HIV disease progression. The present study was conducted to evaluate Candida sp. diversity in the oral cavity of
HIV-infected patients and to determine whether there was association of CD4 + cell count and viral load with asymptomatic oral
Candida carriage. Out of 99 HIV-positive patients studied, 62 (62.6%) had positive culture for Candida (oral carriage) and 37
patients (37.4%) had Candida negative culture (no oral carriage). The etiologic agents most common were C. albicans and C.
tropicalis. The range of CD4 + was 6-2305 cells/mm 3 in colonized patients and 3-839 cells/mm 3 for non-colonized patients, while
the viral load was 60-90016 copies/mL for colonized patients and 75-110488 copies/mL for non colonized patients. The viral load
was undetectable in 15 colonized patients and in 12 non colonized patients. Our results showed that there was no significant
difference of the variables CD4 + cell count and viral load between oral candida carriage and no oral candida carriage patients.
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Palavras-chave
Oral candida, HIV, CD4 + cells, Viral load
Citação
COSTA, Carolina Rodrigues; COHEN, Ana Joaquina; FERNANDES, Orionalda de Fátima Lisboa; MIRANDA, Karla Carvalho; PASSOS, Xisto Sena; SOUZA, Lúcia Kioko Hasimoto; SILVA, Maria do Rosário Rodrigue. Asymptomatic oral cariage of Candida species in HIV -infected patients in the highly active antiretroviral therapy era. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 48, n. 5, p. 257-261, Sept./Oct. 2006.