Immunogenicity of low-dose intramuscular and intradermal vaccination with recombinant Hepatitis B vaccine

Página do item simplificado
dc.creatorTurchi, Marília Dalva
dc.creatorMartelli, Celina Maria Turchi
dc.creatorFerraz, Maria Lucia Cardoso Gomes
dc.creatorSilva, Antônio Eduardo
dc.creatorCardoso, Divina das Dôres de Paula
dc.creatorMartelli, Pierpaolo
dc.creatorOliveira, Lilian Joy W. Antunes
dc.date.accessioned2019-01-18T10:03:59Z
dc.date.available2019-01-18T10:03:59Z
dc.date.issued1997-01
dc.description.abstractThe study is a randomized triai using recombinant DNA vaccine to determine whether an intramuscular 1 O pg dose or intradermal 2 pg induces satisfactory anti-HBs leveis compared to the standard dose of intramuscular 20 pg. Partici­pants were 359 healthy medical and nurse students randomly allocated to one of the three groups: Group I - IM 20 pg; Group II - IM 1 O pg; Group III - ID 2 pg at O, 1 and 6 months. Anti-HBs titres were measured after complete vaccine schedule by ELISA/Pasteur. Baseline variables were similar among groups and side effects were mild after any dose. Vaccinees in the IM-1 O pg group had seroconversion rate anel geometric mean titre (GMT 2344 IU L-1), not significant differcnt from the IM-20 pg group (GMT 4570 IU L 1). On the contrary, 21.4% of the ID - 2 pg recipients mount anti­body concentration below 1 O IU L·1 and GMT of 91 IU L-1, a statistically significant difference compareci with the stan­dard schedule IM-20 pg (p < 0.001). A three dose regimen of half dose IM could be considered an appropriate schedule to prevent hepatitis B in young health adults which is of relevance to the expansion of hepatitis B vaccine programme.pt_BR
dc.identifier.citationTURCH, Marília Dalva; MARTELLI, Celina Maria Turchi; FERRAZ, Maria Lúcia; SILVA, Antonio Eduardo; CARDOSO, Divina das Dores de Paula; MARTELLI, Pierpaolo; OLIVEIRA, Lilian Joy W. Antunes. Immunogenicity of low-dose intramuscular and intradermal vaccination with recombinant Hepatitis B vaccine. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 39, n. 1, p. 15-19, 1997.pt_BR
dc.identifier.doi10.1590/S0036-46651997000100004
dc.identifier.issne- 1678-9946
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16735
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectLow dosespt_BR
dc.subjectHepatitis B vaccinationpt_BR
dc.subjectImmunizationpt_BR
dc.titleImmunogenicity of low-dose intramuscular and intradermal vaccination with recombinant Hepatitis B vaccinept_BR
dc.typeArtigopt_BR

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Artigo - Marília Dalva Turchi - 1997.pdf
Tamanho:
876.46 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

IPTSP - Artigos publicados em periódicos