Methicillin-resistant and vancomycin-intermediate Staphylococcus aureus colonizing patients and intensive care unit environment: virulence profile and genetic variability

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dc.creatorRezende, Jéssica de Oliveira Veloso
dc.creatorCardoso, Juliana Lamaro
dc.creatorNeves, Lorrane Souza
dc.creatorBorges, Lizandra Ferreira de Almeida e
dc.creatorPires, Cyndi Heleinne
dc.creatorLamaro, Luana
dc.creatorGuerreiro, Tainá Carvalho
dc.creatorFerreira, Evelyn M. A.
dc.creatorAndré, Maria Cláudia Dantas Porfírio Borges
dc.date.accessioned2025-07-04T13:31:31Z
dc.date.available2025-07-04T13:31:31Z
dc.date.issued2019
dc.description.abstractThis study aims to determine the prevalence of Staphylococcus aureus colonizing patients and ICU environment of a teaching hospital, the virulence and antimicrobial susceptibility profile of the isolates, and to evaluate the genetic relationship among them. A total of 536 swabs (134 of patients and 402 of ICU environment) were collected and analyzed to detect S. aureus. The antimicrobial susceptibility of the isolates was determined by disk diffusion test, and the detection of the mecA and virulence factors genes was performed by PCR, in addition to SCCmec typing. The genetic similarity of the isolates was determined by PFGE. Staphylococcus aureus was isolated in 12.7% of the swabs. The prevalence of colonization was 13.4% in patients and 12.4% in the environmental samples. The multidrug resistance was determined in 82.4% of the isolates. The prevalence of methicillin-resistant S. aureus was 20.6%, with 50.0% classified as SCCmec IV. The intermediate resistance to vancomycin was detected in 5.9% and 4.4% of the isolates obtained from patients and environment, respectively. Identical isolates obtained from different patients and sources were grouped into several clusters. The results showed dissemination of multidrug-resistant strains between patients and fomites and the persistence of MRSA and VISA isolates in the ICU environment.
dc.identifier.citationVELOSO, Jéssica O. et al. Methicillin-resistant and vancomycin-intermediate Staphylococcus aureus colonizing patients and intensive care unit environment: virulence profile and genetic variability. APMIS, Copenhagen, v. 127, n. 11, p. 717-726, 2019. DOI: 10.1111/apm.12989. Disponível em: https://onlinelibrary.wiley.com/doi/10.1111/apm.12989.Acesso em: 4 jul. 2025.
dc.identifier.doi10.1111/apm.12989
dc.identifier.issn0903-4641
dc.identifier.issne- 1600-0463
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/apm.12989
dc.language.isoeng
dc.publisher.countryOutros
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Restrito
dc.titleMethicillin-resistant and vancomycin-intermediate Staphylococcus aureus colonizing patients and intensive care unit environment: virulence profile and genetic variability
dc.typeArtigo

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