Resultados preliminares com a associação da sulformetoxina à pirimetamina sob a forma injetável * no tratamento da malária por plasmodium falciparum
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Data
1972-06
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Ruy de Souza Lino Júnior
Resumo
The parenteral combination of sulfamethoxine + pyrimethamine
was tested in 25 patients with malária due to P. falciparum
Two dosage schedules were followed.
One group of 14 oligosymptomatic patients with low paràsitemia
received a single I.M. dose. The second group of eleven patients
with severe clinicai manífestations and high parasitemia reçeived one
daily intramuscular injection for two days.
Blood smear controis revealed that in the first group the
asexual forms disappeared between the 2nd 4th days after treatment
in ali 14 patients. 10 patients of the second group showed negative
blood smears between the 3rd and 6th days and one patient died.
Two relapses occurred in the group and one was observed in, the
second group during a control period of cure of 30 days. The patients
remained hospitalizes during this time.
It is concluded that the association of these two drugs when
administered parenterally is well tolerated and highly effective for the
treatment of severe forms of P. falciparum malária in which oral
administration of drugs is often impracticable.
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ALMEIDA NETO, Joaquim Caetano de; VASCONCELOS, Wanderlei Montenegro de Pitaluga.
Preliminary results of parenteral administration of a combination of sulfamethoxine and pyrimethamine for the treatment of plasmodium falciparum malaria. Revista de Patologia Tropical, Goiânia, v. 1, n. 2, p. 251- 258, abr./jun. 1972. Disponível em: < https://www.revistas.ufg.br/iptsp/article/view/23236/13679>.