Viral hepatitis A, B and C in a group of transgender women in central Brazil
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2022
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Transgender women (TGW) have limited access to affordable viral hepatitis testing, hep atitis B vaccination, and treatment. We aimed to estimate the prevalence of viral hepatitis A, B, and
C, as well as to compare the adherence and immunogenicity of two hepatitis B vaccine schedules
among TGW in Central Brazil. A total of 440 TGW were interviewed and tested for hepatitis A, B,
and C serological markers from 2017 to 2018. The hepatitis B vaccine was offered to 230 eligible TGW:
112 received a super accelerated hepatitis B vaccine schedule (G1) and 118 a standard schedule (G2).
The antibody against the hepatitis A virus (HAV) was detected in 75.63% of the participants, and
12.3% of the TGW were exposed to the hepatitis B virus (HBV). Two (0.46%) participants were HBV
carriers. Only 41.5% of the participants showed a serological profile of hepatitis B vaccination. The
antibody against the hepatitis C virus (anti-HCV) was found in six participants (1.37%). Of the TGW
who received the first vaccine dose, 62 (55.36%) and 49 (41.52%) in G1 and G2, respectively, received
three doses (p = 0.036). The vaccine response was evaluated in 28 G1 and 22 G2 TGW; of these,
89.3% and 100% developed protective anti-hepatitis B surface-antigen titers, respectively (p = 0.113).
Since one-third of younger transgender women are susceptible to HAV, hepatitis B immunization is
low, and the anti-HCV rate is higher in this group than in the general population in Central Brazil,
public-health attention is warranted. The super-accelerated scheme demonstrated better adhesion
and good immunogenicity, suggesting that it would be a more cost-effective solution.
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Hepatitis A, Hepatitis B, Hepatitis C, Immunogenicity, Transgender women, Vaccination, Viral hepatitis
Citação
FERRI, Lucila Pessut et al. Viral hepatitis A, B and C in a group of transgender women in central Brazil. Tropical Medicine and Infectious Disease, Basel, v. 7, n. 10, e269, 2022. DOI: 10.3390/tropicalmed7100269. Disponível em: https://www.mdpi.com/2414-6366/7/10/269. Acesso em: 28 fev. 2025.