Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae

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dc.creatorBenjak, Andrej
dc.creatorAvanzi, Charlotte
dc.creatorSingh, Pushpendra
dc.creatorLoiseau, Chloé
dc.creatorGirma, Selfu
dc.creatorBusso, Philippe
dc.creatorFontes, Amanda Nogueira Brum
dc.creatorYuji, Miyamoto
dc.creatorNamisato, Masako
dc.creatorBobosha, Kidist
dc.creatorBührer, Samira
dc.date.accessioned2025-04-15T14:30:35Z
dc.date.available2025-04-15T14:30:35Z
dc.date.issued2018
dc.description.abstractLeprosy is a chronic human disease caused by the yet-uncultured pathogen Mycobacterium leprae. Although readily curable with multidrug therapy (MDT), over 200,000 new cases are still reported annually. Here, we obtain M. leprae genome sequences from DNA extracted directly from patients’ skin biopsies using a customized protocol. Comparative and phylogenetic analysis of 154 genomes from 25 countries provides insight into evolution and antimicrobial resistance, unco vering lineages and phylogeographic trends, with the most ancestral strains linked to the Far East. In addition to known MDT-resistance mutations, we detect other mutations associated with antibiotic resistance, and retrace a potential stepwise emergence of extensive drug resistance in the pre-MDT era. Some of the previously undescribed mutations occur in genes that are appar ently subject to positive selection, and two of these (ribD, fadD9) are restricted to drug-resistant strains. Finally, nonsense mutations in the nth excision repair gene are associated with greater sequence diversity and drug resistance.
dc.identifier.citationBENJAK, Andrej et al. Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae. Nature Communications, London, v. 9, n. 1, e352, 2018. DOI: 10.1038/s41467-017-02576-z. Disponível em: https://www.nature.com/articles/s41467-017-02576-z. Acesso em: 11 abr. 2025.
dc.identifier.doi10.1038/s41467-017-02576-z
dc.identifier.issne- 2041-1723
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/27269
dc.language.isoeng
dc.publisher.countryGra-bretanha
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titlePhylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae
dc.typeArtigo

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