Six cases of Zika/Dengue coinfection in a Brazilian cohort, 2015-2019

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dc.creatorSiqueira, Claudio Morais
dc.creatorFéres, Valéria Christina de Rezende
dc.creatorJunqueira, Isabela Cinquini
dc.creatorCoutinho, Livia
dc.creatorBento, Luziane Mendes
dc.creatorMontes, Larissa
dc.creatorSiqueira Júnior, João Bosco
dc.date.accessioned2025-01-22T12:54:14Z
dc.date.available2025-01-22T12:54:14Z
dc.date.issued2020
dc.description.abstractBrazil is one of the countries which has been most affected by dengue epidemics. This scenario became more challenging with the emergence of Zika virus after 2014. The cocirculation of dengue and Zika viruses makes their diagnosis and treatment a challenge for health professionals, especially due to their similar clinical outcomes. From 2015 to 2019, we followed a cohort of 2017 participants in Goiania, Goias, Central Brazil. Febrile cases were monitored weekly, and after identification of fever, the physician performed a home visit for clinical evaluation and collection of blood/urine for diagnosis of acute dengue/Zika infection in suspected cases. Dengue acute infection was investigated by NS1 antigen and real time RT-PCR and seroconversion of anti-dengue IgM. ZIKV infection was confirmed by real time RT-PCR. Six cases of Zika/dengue coinfection among participants were reported. The clinical outcomes were suggestive for both DENV and ZIKV infection. No coinfected patient had neurological clinical manifestation, warning signs or need for hospitalization. A continuous specific laboratory confirmation for both dengue and Zika viruses should be enforced as part of the surveillance systems even in the presence of very suggestive cases of dengue fever, minimizing the risk of a late detection of ZIKV circulation.
dc.identifier.citationSIQUEIRA, Claudio et al. Six cases of Zika/Dengue coinfection in a Brazilian cohort, 2015-2019. Viruses, Basel, v. 12, n. 10, e1201, 2020. DOI: 10.3390/v12101201. Disponível em: https://www.mdpi.com/1999-4915/12/10/1201. Acesso em: 20 jan. 2025.
dc.identifier.doi10.3390/v12101201
dc.identifier.issne- 1999-4915
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26432
dc.language.isoeng
dc.publisher.countrySuica
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectArboviruses
dc.subjectCoinfection
dc.subjectZika virus
dc.subjectDengue virus
dc.subjectDiagnosis
dc.subjectSigns and symptoms
dc.titleSix cases of Zika/Dengue coinfection in a Brazilian cohort, 2015-2019
dc.typeArtigo

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