Susceptibilidade "in vitro" de cryptococcus neoformans, paracoccidioides brasiliensis, sporothrix schenckii e fonsecaea pedrosoi a esteróides

Abstract

The inhibitory effect of the drugs stilbestrol, estradiol, progesterone and testosterone dissolved in water resulting concentrations of 7,5; 10,0; 12,5 e 15,0 Ug/ml of medhwn were determinated above patterns of Cryptococcus neoformans; Paracoccidioides brasiliensis, Sporothrix schenckii and Fonsecaea pedrosoi. Testosterone didn't show any influence on the development of any from the patterns that were studied. Progesterone and estradiol at 7,5 Ug/ml showed a small inhibition of development of Paracoccidioides brasiliensis and at 15,0 Ug/ml the estradiol showed almost total inhibition on the development of this fungus. The more active drug on the inhibition of ali the fungus, however, was the stilbestrol that in the concentration of 10,0 Ug/ml suppressed completly the development of the Paracoccidioides brasiliensis and on 15,0 Ug/ml inhibited sensibility the development of ali the others fungus that were tested.