Neonatal sepsis and inflammatory mediators

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dc.creatorMachado, Juliana Reis
dc.creatorSoave, Danilo Figueiredo
dc.creatorSilva, Marcos Vinícius da
dc.creatorMenezes, Liliana Borges de
dc.creatorEtchebehere, Renata Margarida
dc.creatorMonteiro, Maria Luiza Gonçalves dos Reis
dc.creatorReis, Marlene Antônia dos
dc.creatorCorrêa, Rosana Rosa Miranda
dc.creatorCeles, Mara Rúbia Nunes
dc.date.accessioned2019-01-24T11:16:06Z
dc.date.available2019-01-24T11:16:06Z
dc.date.issued2014-12-30
dc.description.abstractNeonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult. The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics. Sepsis is the result of an infection associated with a systemic inflammatory response with production and release of a wide range of inflammatory mediators. Cytokines are potent inflammatory mediators and their serum levels are increased during infections, so changes from other inflammatory effector molecules may occur. Although proinflammatory and anti-inflammatory cytokines have been identified as probable markers of neonatal infection, in order to characterize the inflammatory response during sepsis, it is necessary to analyze a panel of cytokines and not only the measurement of individual cytokines. Measurements of inflammatory mediators bring new options for diagnosing and following up neonatal sepsis, thus enabling early treatment and, as a result, increased neonatal survival. By taking into account the magnitude of neonatal sepsis, the aim of this review is to address the role of cytokines in the pathogenesis of neonatal sepsis and its value as a diagnostic criterion.pt_BR
dc.identifier.citationMACHADO, Juliana Reis et al. Neonatal sepsis and inflammatory mediators. Mediators of Inflammation, London, v. 2014, e-269681, 2014.pt_BR
dc.identifier.doi10.1155/2014/269681
dc.identifier.issn0962-9351
dc.identifier.issne- 1466-1861
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16827
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleNeonatal sepsis and inflammatory mediatorspt_BR
dc.typeArtigopt_BR

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