Efeito cicatrizante e atividade antibacteriana da Calendula officinalis L. cultivada no Brasil
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Data
2009
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Resumo
Since ancient history medicinal properties are attributed to flowers of Calendula officinalis
L. (Asteraceae), mainly concerning its healing activity. Studies about the general activity of medicinal
plants in healing wounds have been conducted without specifying in which healing phase the
plant acts. In this work, the anti-inflammatory and healing activity of the ethanolic extract of C.
officinalis flowers cultured in Brazil was evaluated in cutaneous wounds of Wistar rats through
macroscopic and histological evaluation. The antibacterial activity of the extract and dichloromethane
and hexane fractions was also evaluated. The anti-inflammatory activity of calendula ethanolic
extract led to a reduction in plasmatic exudation, hyperemia, fibrin deposition and epidermal
hyperplasia, besides resulting in less edematous crusts. There was also an increase in collagen
in the granulation tissue and an antibacterial effect. Therefore, calendula ethanolic extract positively
acted on the healing process of cutaneous wounds of rats and presented in vitro antibacterial
activity.
Descrição
Palavras-chave
Reparo, Plantas medicinais, Calêndula, Fases da cicatrização, Repair, Medicinal plants, Pot marigold, Healing phases
Citação
PARENTE, L. M. L.; SILVA, M. S. B.; BRITO, L. A. B.; LINO-JUNIOR, R. S.; PAULA, J. R.; TRESVENZOL, L. M. F.; ZATA, D. T.; PAULO, N. M. Efeito cicatrizante e atividade antibacteriana da Calendula officinalis L. cultivada no Brasil. Revista Brasileira de Plantas Medicinais, Botucatu, v. 11, n. 4, p. 383-391, 2009.