Antifungal therapy for systemic mycosis and the nanobiotechnology era: improving efficacy, biodistribution and toxicity
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Data
2017
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Resumo
Fungal diseases have been emerging as an important public health problem worldwide
with the increase in host predisposition factors due to immunological dysregulations,
immunosuppressive and/or anticancer therapy. Antifungal therapy for systemic mycosis
is limited, most of times expensive and causes important toxic effects. Nanotechnology
has become an interesting strategy to improve efficacy of traditional antifungal drugs,
which allows lower toxicity, better biodistribution, and drug targeting, with promising
results in vitro and in vivo. In this review, we provide a discussion about conventional
antifungal and nanoantifungal therapies for systemic mycosis.
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Antifungal therapy, Fungal infection, Mycosis, Nanobiotechnology, Drug delivery systems
Citação
SOUZA, Ana C. O.; AMARAL, Andre C. Antifungal therapy for systemic mycosis and the nanobiotechnology era: improving efficacy, biodistribution and toxicity. Frontiers in Microbiology, Lausanne, v. 8, e:336, 2017. DOI: 10.3389/fmicb.2017.00336. Disponível em: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.00336/full. Acesso em: 8 maio 2025.