Resistência do piasmodium falciparum à associação sulfamidicos-antifólicos na região Centro-Oeste do brasil. dados referentes ao estudo de 104 casos
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Data
1972-09
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Ruy de Souza Lino Júnior
Resumo
From 1966 to the last trimester
of 1972 a sufonamide-antifolic
association was used for the
treatment of 104 cases of falciparum
malária at the Department
of Tropical Medicine of the Institue
of Tropical Pathology of
the Federal University of Goiás.
Ali patients had been hospitalyzed
and were submitted to a cure
control of at least one month.
From 1972 on, there was observed
an increased resistance of falciparum infection to this drug
association.
In this study, the results obtained
with 40 cases until September
1970 are compared with
the results observed in 62 other
cases from January 1971 to May
1972. During the 2nd period, a
decrease in susceptibility of Plasmodium
falciparum, namely, a
slower response and an increased
tendency to recurrences was observed,
including inability to promote
negativation in fíve cases.
By using double dose schedules
with both associations in a
group of 20 patients, a precocious
recrudescence of parasitemia
occurred in 7 cases.
It is concluded that Plasmodium
falciparum is developing a
resistance to the sufonamide-antifolic
association in Goiás.
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ALMEIDA NETTO, Joaquim Caetano de; OLIVEIRA, Giovanni Septimmi Cysneiros de; SAMPAIO, José Alberto Alvarenga. Resistência do piasmodium falciparum à associação sulfamidicos-antifólicos na região Centro-Oeste do brasil. dados referentes ao estudo de 104 casos. Revista de Patologia Tropical, Goiânia, v. 1, n. 3, p. 385- 393, jul./set. 1972. Disponível em: < https://www.revistas.ufg.br/iptsp/article/view/23215/13667>.