Populações de Plasmodium falciparum resistentes a antimaláricos em regiões endêmicas à malária na América do Sul: uma revisão sistemática
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Data
2022
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Resumo
In the Americas, two species of protozoa of the genus
Plasmodium are considered capable of frequently
infecting humans: Plasmodium vivax and Plasmodium
falciparum. The use of antimalarials to control malaria
is an essential alternative in the treatment and control of
the disease. However, the parasite's resistance to the
drug is undoubtedly the main difficulty faced in endemic
regions. Thus, molecular characterizations of resistant
populations and monitoring are essential strategies to
assess the history and spread of resistance. The study
aimed to conduct a systematic review searching for and
analyzing studies that contemplated the resistance
framework of P. falciparum in malaria-endemic regions
in South America. To carry out this work, we searched
for journals indexed in the CAPES periodicals portal
databases, between the years 2007 to 2018, using
previously selected descriptors. A total of 792 articles
were found. After analysis following the inclusion and
exclusion criteria, 456 titles and abstracts were
evaluated and 437 articles were discarded. Thus, 19
articles that dealt with cases of resistant populations of
P. falciparum carried out in South America met the
inclusion criteria. The small number of articles
published and selected in this research does not cover
the situation of P. falciparum resistance in the regions of
South America, which is regrettable, since the American
continent is part of the endemic zone for malaria where
large numbers of reported cases of transmission are
concentrated.
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Palavras-chave
Malária, Plasmodium falciparum, Resistência, América do Sul, Malaria, Plasmodium falciparum, Resistance, South America
Citação
CHAPADENSE, Francesca Guaracyaba et al. Populações de Plasmodium falciparum resistentes a antimaláricos em regiões endêmicas à malária na América do Sul: uma revisão sistemática. Revista Referências em Saúde da Estácio Goiás, Goiânia, v. 5, n. 2, p. 32-41, 2022. Disponível em: https://estacio.periodicoscientificos.com.br/index.php/rrsfesgo/issue/view/370. Acesso em: 30 abr. 2025.