Natural products as leads in schistosome drug discovery

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dc.creatorNeves, Bruno Junior
dc.creatorAndrade, Carolina Horta
dc.creatorCravo, Pedro Vitor Lemos
dc.date.accessioned2018-12-21T12:15:20Z
dc.date.available2018-12-21T12:15:20Z
dc.date.issued2015
dc.description.abstractSchistosomiasis is a neglected parasitic tropical disease that claims around 200,000 human lives every year. Praziquantel (PZQ), the only drug recommended by the World Health Organization for the treatment and control of human schistosomiasis, is now facing the threat of drug resistance, indicating the urgent need for new effective compounds to treat this disease. Therefore, globally, there is renewed interest in natural products (NPs) as a starting point for drug discovery and development for schistosomiasis. Recent advances in genomics, proteomics, bioinformatics, and cheminformatics have brought about unprecedented opportunities for the rapid and more cost-effective discovery of new bioactive compounds against neglected tropical diseases. This review highlights the main contributions that NP drug discovery and development have made in the treatment of schistosomiasis and it discusses how integration with virtual screening (VS) strategies may contribute to accelerating the development of new schistosomidal leads, especially through the identification of unexplored, biologically active chemical scaffolds and structural optimization of NPs with previously established activity.pt_BR
dc.identifier.citationNEVES, Bruno J.; ANDRADE, Carolina H.; CRAVO, Pedro V. L. Cravo. Natural products as leads in schistosome drug discovery. Molecules, Basel, v. 20, p. 1872-1903, 2015.pt_BR
dc.identifier.doi10.3390/molecules20021872
dc.identifier.issn1420-3049
dc.identifier.issne- 1420-3049
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16595
dc.language.isoengpt_BR
dc.publisher.countrySuicapt_BR
dc.publisher.departmentFaculdade de Farmácia - FF (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectVirtual screeningpt_BR
dc.subjectSchistosomiasispt_BR
dc.subjectNatural productspt_BR
dc.subjectLeadspt_BR
dc.subjectChemical scaffoldspt_BR
dc.titleNatural products as leads in schistosome drug discoverypt_BR
dc.typeArtigopt_BR

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