Avaliação da atividade angiogênica da solução aquosa do barbatimão (Stryphnodendron adstringens)
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Data
2016
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Resumo
The Barbatimão (Stryphnodendron adstringens) medicinal plant found in the
Cerrado biome has physicochemical properties which guarantee important pharmacological
activities such as anti-inflammatic, analgesic and protective activities of gastric mucosa. The
bark of the trunk is the main raw material used for the development of medicinal products. In this
study, the objective was to investigate the influence of the aqueous solution of barbatimão bark in
the formation of blood vessels in the membrane of embryonated chicken egg corioalontoid. 30g
of shredded bark was used in one liter of water. This process enabled the obtention of aqueous
Barbatimão - BSA at a concentration of 30mg / ml. The angiogenic activity of the aqueous
solution of barbatimão was assessed by laboratory testing “in vivo”, using the chorioallantoic
membrane of embryonated chicken egg (MCA) as an experimental model. TheRegederm®
controlinductor was used, which exhibits known angiogenic activity. The results showed that
the percentage of BSA showed a vascularization of the MCA (50.4%) there was no difference
(p> 0.05) in the values detected in the control inductor (52.9%). With the obtained results, it is
clear that barbatimão shows angiogenic activity under the experimental model used.
Descrição
Palavras-chave
Angiogênese, Barbatimão, Membrana, Ovo, Angiogenesis, Barbatimão, Membrane, Egg
Citação
CHAVES, D. A. et al. Avaliação da atividade angiogênica da solução aquosa do barbatimão (Stryphnodendron adstringens). Revista Brasileira de Plantas Medicinais, Maringá, v. 18, n. 2, p. 524-530, 2016. DOI: 10.1590/1983-084X/15_093. Disponível em: https://www.scielo.br/j/rbpm/a/kSm6YcvS9fvV9H8B7pFP4Td/abstract/?lang=pt. Acesso em: 10 abr. 2025.