Is there a difference between the preoperative and postoperative serum levels of interleukin-6 and tumor necrosis factor-α in children submitted to adenotonsillectomy?
Nenhuma Miniatura disponível
Data
2022
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Introduction Palatine and pharyngeal tonsils are the first line of defense against
pathogens. Clinically, two alterations may require surgical removal of the tonsils:
hypertrophy and recurrent tonsillitis. The two conditions probably result from a
dysfunction of the immune system.
Objective To evaluate possible differences in the plasma levels of tumor necrosis
factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) in patients submitted to
adenotonsillectomy.
Methods Prospective, longitudinal study with 25 children undergoing adenotonsil lectomy separated into 3 different groups: recurrent tonsillitis (RT), composed of 7
patients; recurrent hypertrophy tonsillitis (RTTH), with 8 patients; and the tonsillar
hypertrophy (TH) group, with 10 patients. Ten healthy control children (SD) were also
included in the study. Peripheral blood was collected, and plasma was separated to
measure the levels of TNF-α, IL-6, and IL-10. The Mann-Whitney test was used for
statistical analysis.
Results The plasma level of IL-6 was higher in the RT (p ¼ 0.0394) and TH (p ¼ 0.0009)
groups, compared with the control group. The TH group also had higher levels of IL-6
than the RT group (p ¼ 0.039). The IL-6/IL-10 ratio was higher in the RT (p ¼ 0.029) and
TH (p ¼ 0.0005) groups compared with the control group. Between the RT and RTTH
groups, the IL-6/IL-10 ratio was higher in the RT group, with a statistically significant
difference (p ¼ 0.0091).
Conclusion Patients with a history of chronic tonsillitis had higher levels of IL-6,
compared with the control group.
Descrição
Palavras-chave
Chronic tonsillitis, Tonsillar hypertrophy, Adenotonsillectomy, Cytokines
Citação
SOUZA, José Neto Ribeiro de et al. Is there a difference between the preoperative and postoperative serum levels of interleukin-6 and tumor necrosis factor-α in children submitted to adenotonsillectomy? International Archives of Otorhinolaryngology, São Paulo, v. 26, n. 2, p. e208-e212, 2021. DOI: 10.1055/s-0041-1730301. Disponível em: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0041-1730301. Acesso em: 17 abr. 2025.