Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene
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2019
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Resumo
Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with
artemisinin resistance. Methods: We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in
a batch of 50 samples collected from 2003 to 2016 in Brazil. Results: We identified 1 K189T substitution located outside the
propeller domain of the PfK13 protein in 36% of samples. Conclusions: Although the sample size is relatively small, these
results suggest that P. falciparum artemisinin-resistant mutants do not exist in Brazil, thereby supporting the continuation of
current treatment programs based on artemisinin-based combination therapy
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Malaria, Plasmodium falciparum, Artemisinin resistance, Kelch 13
Citação
CHAPADENSE, Francesca et al. Plasmodium falciparum malaria parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene. Revista da Sociedade Brasileira de Medicina Tropical, Rio de Janeiro, v. 52, e20180225, 2019. DOI: 10.1590/0037-8682-0225-2018. Disponível em: https://www.scielo.br/j/rsbmt/a/6Kvq9JWDKL5sM334Qdh5jDR/?lang=en. Acesso em: 30 abr. 2025.