Low sensitivity of NS1 protein tests evidenced during a dengue type 2 virus outbreak in Santos, Brazil, in 2010

Página do item simplificado
dc.creatorFelix, Alvina Clara
dc.creatorRomano, Camila Malta
dc.creatorCentrone, Cristiane de Campos
dc.creatorRodrigues, Célia Lima
dc.creatorVillas-Boas, Lucy
dc.creatorAraújo, Evaldo Stanislau
dc.creatorMatos, Andréia Manso de
dc.creatorCarvalho, Karina Inácio
dc.creatorMartelli, Celina Maria Turchi
dc.creatorKallas, Èsper Georges
dc.creatorPannuti, Claúdio Sérgio
dc.creatorLevi, José Eduardo
dc.date.accessioned2019-01-11T11:07:47Z
dc.date.available2019-01-11T11:07:47Z
dc.date.issued2012-11-24
dc.description.abstractIn 2010, a large outbreak of dengue occurred in Santos, Brazil. The detection of the NS1 antigen was used for diagnosis in addi-tion to the detection of IgG, IgM, and RNA. A large number of NS1 false-negative results were obtained. A total of 379 RNA-posi-tive samples were selected for thorough evaluation. NS1 was reactive in 37.7% of cases. Most of the cases were characterized as a secondary infection by dengue 2 virus. Sequencing of NS1 positive and negative isolates did not reveal any mutation that could justify the diagnostic failure. Use of existing NS1 tests in the Brazilian population may present a low negative predictive value, and they should be used with caution, preferentially after performing a validation with samples freshly obtained during the on-going epidemic.pt_BR
dc.identifier.citationFELIX, Alvina Clara et. al. Low sensitivity of NS1 protein tests evidenced during a dengue type 2 virus outbreak in Santos, Brazil, in 2010. Clinical and Vaccine Immunology, Washington, v. 19, n. 12, p. 1972-1976, 2012.pt_BR
dc.identifier.doi10.1128/CVI.00535-12
dc.identifier.issn1556-6811
dc.identifier.issne-1556-679X
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16707
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleLow sensitivity of NS1 protein tests evidenced during a dengue type 2 virus outbreak in Santos, Brazil, in 2010pt_BR
dc.typeArtigopt_BR

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Artigo - Alvina Clara Felix - 2012.pdf
Tamanho:
224.94 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

IPTSP - Artigos publicados em periódicos