Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia
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2020
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Introduction Zika virus (ZIKV) infection in pregnancy
has been associated with microcephaly and severe
neurological damage to the fetus. Our aim is to document
the risks of adverse pregnancy and birth outcomes and the
prevalence of laboratory markers of congenital infection
in deliveries to women experiencing ZIKV infection during
pregnancy, using data from European Commission-funded
prospective cohort studies in 20 centres in 11 countries
across Latin America and the Caribbean.
Methods and analysis We will carry out a centre-by centre analysis of the risks of adverse pregnancy and birth
outcomes, comparing women with confirmed and suspected
ZIKV infection in pregnancy to those with no evidence of
infection in pregnancy. We will document the proportion of
deliveries in which laboratory markers of congenital infection
were present. Finally, we will investigate the associations
of trimester of maternal infection in pregnancy, presence or
absence of maternal symptoms of acute ZIKV infection and
previous flavivirus infections with adverse outcomes and with
markers of congenital infection. Centre-specific estimates
will be pooled using a two-stage approach.
Ethics and dissemination Ethical approval was obtained
at each centre. Findings will be presented at international
conferences and published in peer-reviewed open access
journals and discussed with local public health officials
and representatives of the national Ministries of Health,
Pan American Health Organization and WHO involved with
ZIKV prevention and control activities.
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ADES, A. E. et al. Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia. BMJ Open, London, v. 10, n. 12, e035307, 2020. DOI: 10.1136/bmjopen-2019-035307. Disponível em: https://bmjopen.bmj.com/content/10/12/e035307.long. Acesso em: 18 fev. 2025.