Anti-HCV related to HCV PCR and risk factors analysis in a blood donor population of central Brazil
Carregando...
Data
1994-12
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Data concerning HCV infection in Central Brazil are rare. Upon testing 2,350 voluntary blood donors from this region, we found anti-HCV prevalence rates of 2.2% by a second generation ELISA and 1.4% after confirmation by a line immunoassay. Antibodies against core, NS4, and NS5 antigens of HCV were detected in 81.8%, 72.7%, and 57.5%, respectively, of the positive samples in the line immunoassay. HCV viremia was present in 76.6% of the anti-HCV-positive blood donors. A relation was observed between PCR positivity and serum reactivity in recognizing different HCV antigens in the line immunoassay. The majority of the positive donors had history of previous parenteral exposure. While the combination of ALT>50 IU/l and anti-HBc positivity do not appear to be good surrogate markers for HCV infection, the use of both ALT anti-HCV tests is indicated in the screening of Brazilian blood donors.
Descrição
Palavras-chave
Blood donors, HCV, Anti-HCV, PCR, Risk factors, ALT, Anti-HBc
Citação
MARTINS, R. M. B. et al. Anti-HCV related to HCV PCR and risk factors analysis in a blood donor population of central Brazil. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 36, n. 6, p. 501-506, 1994.