Human genetic susceptibility of leprosy recurrence
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2020
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Host genetic susceptibility to leprosy has been intensively investigated over the last decades; however,
there are no studies on the role of genetic variants in disease recurrence. A previous initiative identifed
three recurrent cases of leprosy for which none of the M. leprae strains, as obtained in the frst and the
second diagnosis, had any known genomic variants associated to resistance to Multidrug therapy;
in addition, whole genome sequencing indicated that the same M. leprae was causing two out of the
three recurrences. Thus, these individuals were suspected of being particularly susceptible to M. leprae
infection, either as relapse or reinfection. To verify this hypothesis, 19 genetic markers distributed
across 11 loci (14 genes) classically associated with leprosy were genotyped in the recurrent and in three
matching non-recurrent leprosy cases. An enrichment of risk alleles was observed in the recurrent cases,
suggesting the existence of a particularly high susceptibility genetic profle among leprosy patients
predisposing to disease recurrence.
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SARTORI, Priscila Verchai Uaska et al. Human genetic susceptibility of leprosy recurrence. Scientific Reports, London, v. 10, n. 1, p. 1284-1289, 2020. DOI: 10.1038/s41598-020-58079-3. Disponível em: https://www.nature.com/articles/s41598-020-58079-3. Acesso em: 11 fev. 2025.