Sensitization with atypical mycobacteria is a potent risk factor for cross-reaction with the delayed type hypersensitivity assay in mice

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dc.creatorSousa, Eduardo Martins de
dc.creatorBortoli, Fernando Bonfim de
dc.creatorSilva, Bruna Daniella de Souza
dc.creatorSilva, Ediane Batista da
dc.creatorScott M, Irwin
dc.creatorJunqueira-Kipnis, Ana Paula
dc.date.accessioned2018-12-12T11:55:45Z
dc.date.available2018-12-12T11:55:45Z
dc.date.issued2010-07-14
dc.description.abstractTuberculosis is a disease that infects approximately two billion people worldwide. The current diagnostic test utilizes purified protein derivative (PPD) obtained from Mycobacterium tuberculosis cultures to elicit a host delayed type hypersensitivity reaction to identify infected individuals. This reaction is manifested as an induration at 48 hours following intradermal i njection. These experiments demonstrate that in a mouse model, repeated administrations of PPD do not elicit a positive tuberculin skin test (TST). However, prior sensitization to environmental mycobacteria does induce a positive TST when administered via the intraperitoneal or oral route. This work has important implications regarding the specificity of the PPD reagent, disease diagnosis, and environmental mycobacteria.pt_BR
dc.identifier.citationSOUSA, Eduardo Martins de Sousa; BORTOLI, Fernando Bonfim de; SILVA, Bruna Daniella de Souza; SILVA, Ediane Batista da; IRWIN, Scott M; JUNQUEIRA-KIPNIS, Ana Paula. Sensitization with atypical mycobacteria is a potent risk factor for cross-reaction with the delayed type hypersensitivity assay in mice. Pathology and Laboratory Medicine International, London, p. 91-97, 2010.pt_BR
dc.identifier.doi10.2147/PLMI.S11703
dc.identifier.isbne- 1179-2698
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16570
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectImmune responsept_BR
dc.subjectTuberculin skin testpt_BR
dc.subjectEnvironmental mycobacteriapt_BR
dc.titleSensitization with atypical mycobacteria is a potent risk factor for cross-reaction with the delayed type hypersensitivity assay in micept_BR
dc.typeArtigopt_BR

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