Hydrogel-based dressings in the treatment of partial thickness experimentally induced burn wounds in rats
Nenhuma Miniatura disponível
Data
2023
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Purpose: To compare four commercially available hydrogel formulations in the healing of partial thickness burns experimentally
induced in rats. Methods: Wistar rats were used, and after the burn wound induction they were divided into the following
treatment groups: G1) NaCl 0.9%; G2) 1% silver sulfadiazine; G3) Debrigel™; G4) Safgel™; G5) Dersani™; G6) Solosite™. The animals
were followed during seven, 14 and 30 days after the injury induction. Morphometric, macroscopic and microscopic evaluations
were performed. Results: The treatment with Dersani™ induced better results during the inflammatory and proliferative phases
of the healing process (p<0.05). The animals treated with Safgel™ presented better scaring in the remodeling phase (p<0.05), and
the treatment with Dersani™ and Solosite™ induced greater wound closure (p<0.05). Conclusion: The hydrogel-based dressings
presented beneficial outcomes in the healing of burn wounds experimentally induced in rats due to their ability in maintain the
humidity of the wound, in removing the exudate, in promoting cell migration and collagen production during the different phases
of the healing process.
Descrição
Palavras-chave
Burns, Wound healing, Hydrogels, Rats
Citação
BERNARDES, Milton Junior Cândido et al. Hydrogel-based dressings in the treatment of partial thickness experimentally induced burn wounds in rats. Acta Cirúrgica Brasileira, São Paulo, v. 37, n. 4, e370401, 2022. DOI: 10.1590/acb370401. Disponível em: https://www.scielo.br/j/acb/a/cNW68RkWRDGHBXPCRrwnpfP/?lang=en. Acesso em: 20 fev. 2025.