Quadro histopatológico em camundongos isogênicos C3H/HeJ e C57BL/10 na fase aguda da infecção com cepas de trypanosoma cruzi isoladas nas regiões central (Goiás) e sul (Rio Grande do Sul) do Brasil
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Data
1997-10
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Título de Volume
Editor
Ruy de Souza Lino Junior
Resumo
The histopathological lesions determined in isogenic C3H and B10
mice infected with T. cruzi strains isolated from naturally infected
triatominae from four different localities of the Goiás State, Brasil, (Mambaí,
Cabeceiras, Niquelândia and Taguatinga) were studied and compared with
another strain from Rio Grande do Sul State. The several isolates from Goiás
have been previously characterized according to their biological and
biochemical behavior as Type II and zymodeme 2. Histopathological studies
have shown similar tropism and tissue lesions for the four strains from Goiás.
Cardiac lesions were predominant, with moderate diffuse mononuclear
infíltration and myocardial cells parasitism. Skeletal muscle lesions were
scarce or absent and macrophagotropism occurred only exceptionally. The
lesions were identical for the two strains of mice being slightly more intense
in C3H mice with the four T. cruzi studied strains. The strain from Rio
Grande do Sul State, characterized as Type III, zymodeme l, determined
skeletal muscle lesions and predominance of lesions in B10 mice. The
present investigation confírms previous observations showing that the Type
II strains are predominant in the central region of Brazil and this may be
correlated with the Chagas disease manífestations in this área.
Descrição
Palavras-chave
Trypanosoma cruzi, Cepas, Patologia experimental, Camundongos isogênicos, Doença de chagas, Strains, Experimental pathology, Inbred mice, Chagas disease
Citação
MARTINS, Helena Maria Bringel; ALVES, Maria de Fátima Costa; SILVEIRA, Lucimeire Antonelli da; PFRIMER, Irmtraut Araci Hoffman; ANDRADE, Sônia Gumes. Quadro histopatológico em camundongos isogênicos C3H/HeJ e C57BL/10 na fase aguda da infecção com cepas de trypanosoma cruzi isoladas nas regiões central (Goiás) e sul (Rio Grande do Sul) do Brasil. Revista de Patologia Tropical, Goiânia, v. 26, n. 2, p. 189-198, jul./dez. 1997. Disponível em: <https://www.revistas.ufg.br/iptsp/article/view/17232/10376>.