Late onset of antiretroviral therapy in adults living with HIV in an urban area in Brazil: prevalence and risk factors

Página do item simplificado
dc.creatorPacheco, Priscila Ribeiro Guimarães
dc.creatorZara, Ana Laura Sene Amâncio
dc.creatorSouza, Luiz Carlos Silva
dc.creatorTurchi, Marília Dalva
dc.date.accessioned2025-02-20T11:20:25Z
dc.date.available2025-02-20T11:20:25Z
dc.date.issued2019
dc.description.abstractHighly active antiretroviral therapy has been available since 1996. Early initiation of antiretroviral therapy (ART) leads to improved therapeutic response and reduced HIV transmission. However, a signifcant number of people living with HIV (PLHIV) still start treatment late. Objective. Tis study aimed to analyze characteristics and factors associated with late initiation of ART among HIV-infected treatment-na¨ıve patients. Methods. Tis cross-sectional study included PLHIV older than 17 years who initiated ART at two public health facilities from 2009 to 2012, in a city located in Midwestern Brazil. Pregnant women were excluded. Data were collected from medical records, antiviral dispensing forms, and the Logistics Control of Medications System (SICLOM) of the Brazilian Ministry of Health. Late initiation of ART was defned as CD4+ cell count < 200 cells/mm3 or presence of AIDS-defning illness. Uni- and multivariate analysis were performed to evaluate associated factors for late ARV using SPSS , version 21. Te signifcance level was set at p<0.05. Results. 1,141 individuals were included, with a median age of 41 years, and 69.1% were male. Te prevalence of late initiation of ART was 55.8% (95%CI: 52.9-58.7). Te more common opportunistic infections at ART initiation were pneumocystosis, cerebral toxoplasmosis, tuberculosis, and histoplasmosis. Overall, 38.8% of patients had HIV viral load equal to or greater than 100,000 copies/mL. Late onset of ART was associated with higher mortality. Afer logistic regression, factors shown to be associated with late initiation of ARV were low education level, sexual orientation, high baseline viral load, place of residence outside metropolitan area, and concomitant infection with hepatitis B virus. Conclusion. Tese results revealed the need to increase early treatment of HIV infection, focusing especially on groups of people who are more socially vulnerable or have lower self-perceived risk.
dc.identifier.citationPACHECO, Priscila Ribeiro Guimarães et al. Late onset of antiretroviral therapy in adults living with HIV in an urban area in Brazil: prevalence and risk factors. Journal of Tropical Medicine, Cairo, v. 2019, e5165313, 2019. DOI: 10.1155/2019/5165313. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2019/5165313. Acesso em: 18 fev. 2025.
dc.identifier.doi10.1155/2019/5165313
dc.identifier.issne- 1687-9694
dc.identifier.issn1687-9686
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26727
dc.language.isoeng
dc.publisher.countryOutros
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleLate onset of antiretroviral therapy in adults living with HIV in an urban area in Brazil: prevalence and risk factors
dc.typeArtigo

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
Artigo - Priscila Ribeiro Guimarães Pacheco - 2019.pdf
Tamanho:
457.84 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

IPTSP - Artigos publicados em periódicos