Morphometric analysis and virulence of isolates of toxoplasma gondii recovered from pregnant and newborn mice in Goiânia-GO
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2018
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Introduction: Studies in Toxoplasma gondii
performed in newborns are interesting and
relevant because they induce serious injuries in
newborns when they are not properly treated.
Objective: To perform morphometric analyses of
Toxoplasma gondii isolated (Tachizoite forms),
recovered from peritoneal exudation in mice
infected with biological material recovered from
pregnant women and newborns in Goiânia-GO.
Methodology: Three isolates of Toxoplasma
gondii in newborns and the RH lineage were
evaluated as to the pathogenicity and virulence in
Balb-c albino mice. The suspension of Taquizoito
used in experimental tests was obtained by
puncture or washing of the peritoneal cavity in
mice with ascites. Each sample was inoculated
into groups of four mice with inoculators of 10, 10,
10, 10, 10, 10 taquizoitos living, via intra
peritoneum.
Results and discussion: It was discovered that
the isolates 15, 20 and RH lineage were lethal in
mice. The isolate-3 behaved lethally in all mice up
to 10 taquizoítos. The death of all animals that
presented acute infection occurred 5-10 days after
inoculation. Insulated-15, insulated-20 and RH
strains showed greater diameter and smaller areas
compared to the insulated-3. It turned out that the
most virulent isolate also demonstrated greater
area and diameter, and these findings reinforce
the hypothesis that, in addition to behavioral
differences and genetic variations, there are also
morphological variations when different strains of
T. gondii are evaluated.
Final considerations: This new morphometric
parameter corroborates the presence of diversity
between isolated strains and may constitute new
information used to characterize and analyze
these strains.
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Toxoplasma gondii, Isolate, Newborn, Toxoplasma gondii, Isolar, Recém-nascido
Citação
SILVA, Marcos Gontijo da et al. Morphometric analysis and virulence of isolates of toxoplasma gondii recovered from pregnant and newborn mice in Goiânia-GO. Revista Amazônia Science & Health, Gurupi, v. 6, p. 48-53, 2018. DOI: 10.18606/2318-1419/amazonia.sci.health.v6n1p48-53. Disponível em: https://ojs.unirg.edu.br/index.php/2/article/view/2023. Acesso em: 30 abr. 2025.