Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis
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Data
2016
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Resumo
Neurocysticercosis (NCC) is the most severe clinical manifestation of cysticercosis. One of the factors responsible for its symptomatology
is the host inflammatory response. Therefore the influence of interleukin 4 (IL-4) on the induction of encephalitis in experimental NCC was
evaluated. Methods: BALB/c (WT) and BALB/c (IL-4-KO) mice were inoculated intracranially with Taenia crassiceps cysticerci and euthanized
at 7, 30, 60 and 90 days later, the encephala removed and histopathologically analyzed. Results: The absence of IL-4 induced greater
parasitism. In the initial phase of the infection, IL-4-KO showed a lower intensity in the inflammatory infiltration of polimorphonuclear
cells in the host-parasite interface and intra-parenquimatous edema. The IL-4-KO animals, in the late phase of the infection, showed
lower intensity of ventriculomegaly, encephalitis, and meningitis, and greater survival of the parasites in comparison with the WT animals.
Conclusion: The absence of IL-4 induced lower inflammatory infiltration, ventriculomegaly and perivasculitis in experimental NCC.
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Neurocisticercose, Taenia crassiceps, Encefalite, Interleukin-4, Neurocysticercosis, Taenia crassiceps, Encephalitis, Interleukin-4
Citação
SILVA, Hidelberto Matos; VINAUD, Marina Clare; LINO JUNIOR, Ruy de Souza. Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis. Arquivos de Neuro-Psiquiatria, São Paulo, v. 75, n. 2, p. 96-102, 2017. DOI: 10.1590/0004-282X20160194. Disponível em: https://www.scielo.br/j/anp/a/vMYFC4PTwn58T4c9Q8wKdNm/?lang=en. Acesso em: 21 fev. 2025.