Resposta inflamatória e deposição de colágeno após implante intramuscular com polimetilmetacrilato em camundongos Balb/c

Resumo

The tissues felling with particles has been widely used, however it is necessary to study possible adverse reactions of these application. This study evaluated the inflammation response of collagen after intramuscular implant of polymethilmethacrylate (PMMA) in Balb/c mice. It was implanted 100 ìl of PMMA in left hind, later the muscles were weighed with and without implants and tissue was colleted for histopathological and immunohistochemical analysis. In the morphom- etry found microspheres of 10.9 and 15 μm. There was a difference in the weight of the muscles p<0,01. The macrophages phagocyting PMMA were found and there was a deposit of collagen in the conjuntive tissue. In the immunohistochemical analysis the cells presented positive marking for CD68. The microspheres of PMMA did not lead to a chronic inflammatory response.

Descrição

Palavras-chave

Fagocitose, Polimetilmetacrilato, Inflamação, Polimetilmetacrilato, Inflamation, Polymethilmethacrylate, Phagocitose

Citação

SOUSA, Eduardo Martins; COSTA, Eduardo Luiz; SILVA, Ediane Batista; ARAÚJO FILHO, João Alves; LINO-JUNIOR, Ruy Souza; JUNQUEIRA-KIPNIS, Ana Paula. Resposta inflamatória e deposição de colágeno após implante intramuscular com polimetilmetacrilato em camundongos Balb/c. Acta Scientiae Veterinariae, Porto Alegre, v. 36, n. 1, p. 13-19, 2008.