Cardiotoxicity of chemotherapy drugs and possible protective effects of physical exercise: a literature review
Nenhuma Miniatura disponível
Data
2016
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
This review was designed to summarize the main pathophysiological mechanisms of doxorubicin
cardiotoxicity and the positive effects of physical exercise. Objective: To characterize a literature
review on the main cardiotoxicity mechanisms already described and what possible strategies
attenuate and/or prevent these side effects, with a focus on physical exercise. Methods: A
literature search using PubMed (MEDLINE) and SciELO databases was conducted covering the
articles published between 2000 and 2015. These studies were selected for posterior analysis,
according to pre-established criteria. Results: Fifty-eight (58) articles based on references and
according to the descriptors were found and 45 articles were included: 18 reviews, 19 articles
developed with animal experiments, 07 articles with studies in humans and 01 guideline.
Conclusion: Data analysis led us to understand that although there is no consensus about the
doxorubicin mechanism of action that causes toxicity, the generation of reactive oxygen species
and changes in intracellular calcium are the most studied mechanisms and provide the most
evidence in literature. Other studies are still needed to elucidate the complex cardiotoxicity
mechanisms and which strategies would be the best for cardioprotection. A possible therapeutic
strategy that has been studied is implementing exercise, but some questions still arise, including:
1) What would be the best time to implement an exercise program, before or during
chemotherapy? And 2) Could exercise play a cardioprotective role in preventing or attenuating
toxic effects on the heart?
Descrição
Palavras-chave
Citação
COSTA, Thalyta Rocha et al. Cardiotoxicity of chemotherapy drugs and possible protective effects of physical exercise: a literature review. Journal of Respiratory and Cardiovascular Physical Therapy, Natal, v. 4, n. 2, p. 7-17, 2016. Disponível em: https://periodicos.ufrn.br/revistadefisioterapia/article/view/8909/8217. Acesso em: 6 fev. 2025.