Partial inhibition of the main energetic pathways and its metabolic consequences after in vivo treatment with benzimidazole derivatives in experimental neurocysticercosis

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dc.creatorPicanço, Guaraciara de Andrade
dc.creatorLima, Nayana Ferreira de
dc.creatorGomes, Taynara Cristina
dc.creatorFraga, Carolina Miguel
dc.creatorAlves, Daniella de Sousa Mendes Moreira
dc.creatorCastillo Bocanegra, Rafael
dc.creatorCosta, Tatiane Luiza da
dc.creatorLino Junior, Ruy de Souza
dc.creatorAmbrosio Hernandez, Javier R.
dc.creatorVinaud, Marina Clare
dc.date.accessioned2025-02-27T13:10:56Z
dc.date.available2025-02-27T13:10:56Z
dc.date.issued2019
dc.description.abstractBenzimidazole derivatives such as albendazole (ABZ) and mebendazole are important molecules used in helminthic treatment. Neurocysticercosis is the main cause of acquired epilepsy throughout the world and is currently treated with ABZ. New molecules have been studied in order to aid in the treatment of this neglected tropical disease, among them RCB15 and RCB20. The aim of this study was to evaluate the metabolic impact of RCB15 and RCB20 on Taenia crassiceps cysticerci intracranially inoculated in Balb/c mice. Thirty days after the inoculation the mice were treated with 50 mg kg-1 of RCB15, RCB20, ABZ or NaCl 0.9%. The euthanasia and cysticerci removal were performed 24 h after the treatment. The cysticerci were analysed through high performance liquid chromatography. After the treatments, there was an impairment in the main energetic pathways such as glycolytic pathway, homolactic fermentation or in mitochondrion energy production detected through the decrease in pyruvate, lactate, oxaloacetate, malate and fumarate concentrations. This induced the parasite to resort to alternative energetic pathways such as proteins catabolism, propionate fermentation and fatty acids oxidation. Therefore, benzimidazole derivatives are a promising alternative to ABZ use as they also reach the brain tissue and induce a metabolic stress in the cysticerci.
dc.identifier.citationPICANÇO, Guaraciara de Andrade et al. Partial inhibition of the main energetic pathways and its metabolic consequences after in vivo treatment with benzimidazole derivatives in experimental neurocysticercosis. Parasitology, London, v. 146, n. 12, p. 1578-1582, 2019. DOI: 10.1017/S0031182019000933. Disponível em: https://www.cambridge.org/core/journals/parasitology/issue/040E1323DD719B1333A86AB94211B289. Acesso em: 21 fev. 2025.
dc.identifier.doi10.1017/S0031182019000933
dc.identifier.issn0031-1820
dc.identifier.issne- 1469-8161
dc.identifier.urihttps://www.cambridge.org/core/journals/parasitology/issue/040E1323DD719B1333A86AB94211B289
dc.language.isoeng
dc.publisher.countryGra-bretanha
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Restrito
dc.subjectAlternative energetic pathways
dc.subjectRCB15
dc.subjectRCB20
dc.subjectBenzimidazole derivatives
dc.subjectExperimental neurocysticercosis
dc.subjectFermentation
dc.titlePartial inhibition of the main energetic pathways and its metabolic consequences after in vivo treatment with benzimidazole derivatives in experimental neurocysticercosis
dc.typeArtigo

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