Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the murine model
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2004-06
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The goal of this study was to investigate the pattern of inflammatory response induced by Lagochilascaris minor
in murine experimental model. For this purpose 115 mice were given 1000-3000 L. minor infective eggs “per os” and
51 uninfected mice were considered as controls. Four hours post-inoculation (PI), 3rd stage larvae were seen
passing through the mucosa of terminal ends of small intestine. Six hours PI larvae were observed as an embolus
inside the portal vein and also migrating through the liver parenchyma. During the first 24 h larvae-containing
eggs of L. minor were observed in the lumen of intestinal tract. Two days PI larvae were seen migrating through lung
parenchyma associated with an initial neutrophilic perivasculitis. From the 13th day of this experimental study, L.
minor larvae were found mainly in skeletal muscles, in the center of granulomas. Concentric fibrosis with mixed
inflammatory infiltrate involved the larvae after the 47th day PI, persistently. This experimental murine study with L.
minor indicated that the 3rd stage larvae penetrated via ileum-cecal mucosa reaching the liver and probably other
tissues through the hematogenic via. Throughout its pathway the larvae induced a granulomatous reaction, with
abundant polimorphonuclear cells.
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Lagochilascaris minor, Experimental infection, Inflammatory response
Citação
SEMERENE, Amélia Regina; LINO JUNIOR, Ruy de Souza; OLIVEIRA, Jayrson Araújo; MAGALHÃES, Albino Verçosa; STEFANI, Mariane Martins Araújo; BARBOSA, Alverne Passos; CAMPOS, Dulcinéa Maria Barbosa. Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the murine model. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 393-398, June. 2004.