Prevalence and genetic characterisation of HTLV-1 and 2 dual infections in patients with pulmonary tuberculosis in central-west Brazil
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Data
2014-02
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Resumo
Human T-cell lymphotropic virus (HTLV) may impact the clinical course of tuberculosis (TB). Both infections are
highly endemic in Brazil. The aim of this study was to assess the prevalence of HTLV-1/2 in TB patients in Central-
West Brazil and to perform a genetic characterisation of the respective isolates. Of the 402 patients, six (1.49%) were
positive for anti-HTLV and five (1.24%; 95% confidence interval: 0.46-3.05) were infected with HTLV-1/2. Genetic
characterisation demonstrated that the four HTLV-1 isolates belonged to the Transcontinental subgroup A of the
Cosmopolitan subtype a and that the HTLV-2 isolate belonged to subtype a (HTLV-2a/c). The prevalence of HTLV
infection observed in this study is higher than that observed in local blood donors and the HTLV-1 and 2 subtypes
identified are consistent with those circulating in Brazil.
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HTLV-1, Prevalence, Tuberculosis, HTLV-2
Citação
KOZLOWSKI, Aline Garcia; CARNEIRO, Megmar Aparecida dos Santos; MATOS, Márcia Alves Dias de; TELES, Sheila Araujo; ARAUJO FILHO, João Alves; OTSUKI, Koko; VICENTE, Ana Carolina Paulo; MARTINS, Regina Maria Bringel. Prevalence and genetic characterisation of HTLV-1 and 2 dual infections in patients with pulmonary tuberculosis in Central-West Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, p. 118-121, Feb. 2014.