Identification of biomarkers for diagnosis and prognosis of congenital and acute toxoplasmosis

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dc.creatorStorchilo, Heloisa Ribeiro
dc.creatorTeixeira, Giulianne Monteiro
dc.creatorMoreira, André Luís Elias
dc.creatorGomes, Taynara Cristina
dc.creatorBorges, Clayton Luiz
dc.creatorCastro, Ana Maria de
dc.date.accessioned2025-05-07T12:09:46Z
dc.date.available2025-05-07T12:09:46Z
dc.date.issued2021
dc.description.abstractBackground. The diagnosis of congenital toxoplasmosis can be inconclusive in many cases. Despite the several serological tests developed, the literature on biomarkers that can assist in the diagnosis of congenital an acute toxoplasmosis is limited. The objective of this study was to analyze the immunoreactive profile of Toxoplasma gondii protein bands with the potential to be biomarkers for diagnosis and prognosis of congenital and acute toxoplasmosis. Methods. Peripheral blood samples from women of childbearing age and/or pregnant women diagnosed with acquired tox oplasmosis as well as from congenitally infected children were selected and submitted to immunoblotting for analysis of the immunoreactive bands profile by immunoglobulin G (IgG) antibodies. Results. When comparing the immunoreactive bands profile for antibodies present in samples from different groups and sub groups, the 150, 18.5, and 16.96-kDa bands were more immunoreactive with the antibodies present in serum samples from the acquired infection group. The 343, 189, 150, 75, and 42-kDa bands showed more chance to be detected by the symptomatic congen ital infection subgroup samples, while the 61, 50, and 16.96-kDa bands were significantly immunoreactive with the acute infection subgroup samples. Conclusions. The identification of these potential biomarkers can assist in early diagnosis and treatment of congenital toxoplasmosis
dc.identifier.citationSTORCHILO, Heloisa Ribeiro et al. Identification of biomarkers for diagnosis and prognosis of congenital and acute toxoplasmosis. Journal of Infectious Diseases, Oxford, v. 223. n. 11, p. 1965-1972, 2021. DOI: 10.1093/infdis/jiaa613. Disponível em: https://academic.oup.com/jid/article/223/11/1965/5913182?login=true. Acesso em: 6 maio 2025.
dc.identifier.doi10.1093/infdis/jiaa613
dc.identifier.issn0022-1899
dc.identifier.issn1537-6613
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/27460
dc.language.isoeng
dc.publisher.countryGra-bretanha
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectImmunoblotting
dc.subjectCongenital toxoplasmosis
dc.subjectPrognosis
dc.titleIdentification of biomarkers for diagnosis and prognosis of congenital and acute toxoplasmosis
dc.typeArtigo

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