False-negative result of serum cryptococcal antigen lateral flow assay in an HIV-infected patient with culture-proven cryptococcaemia

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dc.creatorBorges, Moara Alves Santa Bárbara
dc.creatorAraújo Filho, João Alves de
dc.creatorSoares, Renata de Bastos Ascenço
dc.creatorVidal Bermúdez, José Ernesto
dc.creatorTurchi, Marília Dalva
dc.date.accessioned2025-01-20T10:52:34Z
dc.date.available2025-01-20T10:52:34Z
dc.date.issued2019
dc.description.abstractThe detection of cryptococcal capsular antigen (CrAg) is very sensitive and specific, however false-negative results have been reported, mostly in cerebrospinal fluid. We report the case of an HIV-infected patient with CD4 = 42 cells/mL, asthenic, negative serum CrAg lateral flow assay (LFA) and culture-proven cryptococcaemia. Despite the high accuracy of LFA, false-negative result is possible. Careful clinical evaluation and close follow-up are relevant.
dc.identifier.citationBORGES, Moara Alves Santa Bárbara et al. False-negative result of serum cryptococcal antigen lateral flow assay in an HIV-infected patient with culture-proven cryptococcaemia. Medical Mycology Case Reports, Amsterdam, v. 26, p. 64-66, 2019. DOI: 10.1016/j.mmcr.2019.10.009. Disponível em: https://www.sciencedirect.com/science/article/pii/S2211753919300909?via%3Dihub. Acesso em: 17 jan. 2025.
dc.identifier.doi10.1016/j.mmcr.2019.10.009
dc.identifier.issne- 2211-7539
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26419
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCryptococcosis
dc.subjectAIDS
dc.subjectFungal antigens
dc.subjectFalse negative reaction
dc.subjectProzone effect
dc.titleFalse-negative result of serum cryptococcal antigen lateral flow assay in an HIV-infected patient with culture-proven cryptococcaemia
dc.typeArtigo

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