Carboxymethyl chitosan hydrogel formulations enhance the healing process in experimental partial-thickness (second-degree) burn wound healing
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2021
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Purpose: This study aimed to elaborate a hydrogel constituted by carboxymethyl chitosan (CMC), hyaluronic
acid (HA) and silver (Ag) and to evaluate its healing effect on partial-thickness burn wounds experimentally
induced in rats. Methods: CMC was obtained by chitosan reacting with monochloroacetic acid. The
carboxymethylation was confirmed by Fourier-transform infrared spectroscopy and hydrogen nuclear
magnetic resonance (NMR). Scanning electron microscopy was used to determine the morphological
characteristics of chitosan and CMC. After the experimental burn wound induction, the animals (n = 126)
were treated with different CMC formulations, had their occlusive dressings changed daily and were
followed through 7, 14 and 30 days. Morphometric, macroscopic and microscopic aspects and collagen
quantification were evaluated. Results: Significative wound contraction, granulation tissue formation,
inflammatory infiltration and collagen fibers deposit throughout different phases of the healing process
were observed in the CMC hydrogels treated groups. Conclusion: The results showed that, in the initial
phase of the healing process, the most adequate product was the CMC/HA/Ag association, while in the
other phases the CMC/HA association was the best one to promote the healing of burn wounds.
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Hydrogels, Carboxymethyl chitosan, Experimental burn wound, Rats, General pathologic processes
Citação
GONÇALVES, Randys Caldeira et al. Carboxymethyl chitosan hydrogel formulations enhance the healing process in experimental partial-thickness (second-degree) burn wound healing. Acta Cirúrgica Brasileira, São Paulo, v. 36, n. 3, e360303, 2021. DOI: 10.1590/ACB360303. Disponível em: https://www.scielo.br/j/acb/a/tkpGLjfBt3fNzDkYfL4pw5R/?lang=en. Acesso em: 20 fev. 2025.