Mestrado em Ciências Fisiológicas Multicêntrico (ICB)
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Item Contribuição dos receptores de grelina dos neurônios pré-motores simpáticos do hipotálamo paraventricular para o controle da função cardiovascular(Universidade Federal de Goiás, 2018-05-09) Santana, Joice Simões; Custódio, Carlos Henrique Xavier; http://lattes.cnpq.br/0207928273284808; Ferreira, Reginaldo Nassar; http://lattes.cnpq.br/2555785079833283; Ferreira, Reginaldo Nassar; Custódio, Carlos Henrique Xavier; Ferreira, Patrícia Maria; Colugnati, Diego Basileon the balance of the excitatory and inhibitory synapses, such as gabaergic ones, is responsible for cardiovascular system modulation. The effects of ghrelin, a 28-amino acids peptide, are mediated by subtype 1a of the growth hormone secretagogue receptor (GHSR1a), densely expressed in the sympathetic pre-motor neurons of PVH. Therefore, this work investigated the effects of ghrelin on the control exercised by PVH on cardiovascular system and its relationship with gabaergic activity. For this purpose, mean systemic arterial pressure (PAM) in the femoral artery and pressure in the left cardiac ventricle (LVP) of Wistar rats (250-300 g) were measured by catheterization. Treatment with 100 nL of 0.03 nM ghrelin injected directly into PVH reduced PAM by 40 ± 12 mmHg and the maximum blood pressure in the left cardiac ventricle (LVPmax) by 28 ± 12 mmHg, as well as its derivative as a function of time (LVdP / dTmax), a measure of inotropism, which was reduced by 2051 ± 946 mmHg / s, without causing statistically significant changes in cardiac chronotropism. In contrast, to demonstrate that the effects of ghrelin were mediated by GHS-R1a, the inhibition of this receptor with 100 nL of PF04628935 (0.06 nM) in PVH caused an increase in PAM of 8 ± 3 mmHg and of LVPmax by 29 ± 8 mmHg; in addition to stimulating inotropism, with LVdP / dTmax being elevated at 1449 ± 467 mmHg / s, and chronotropism, with elevated heart rate at 29 ± 12 bpm. Finally, the comparison of its effects with muscimol, a GABAA receptor agonist, demonstrated that ghrelin potentiated the reduction in blood pressure induced by that drug, reducing PAM by 19 ± 5 mmHg, without significantly altering the pressure in the cardiac left ventricle and inotropism. Interestingly, ghrelin promoted na increase in heart rate by 27 ± 12 bpm, after muscimol injection. The present study demonstrated that the ghrelin axis - GHS-R1a in PVH contributes to cardiovascular control and related these effects to interactions with the gabaergic system.Item Efeito do extrato líquido concentrado obtido dos resíduos agroindustriais dos frutos de Myrciaria cauliflora sobre parâmetros cardiometabólicos de ratos Wistar submetidos ao modelo de obesidade induzida por glutamato monossódico(Universidade Federal de Goiás, 2020-02-13) Teófilo , Monatha Nayara Guimarães T; Blanch, Graziela Torres; http://lattes.cnpq.br/8106735874828106; Oliveira , André Henrique Freiria; http://lattes.cnpq.br/0152151142555605; Oliveira , André Henrique Freiria; Rosa, Daniel Alves; Fajemiroye, James OluwagbamigbeObesity is a multifactorial disease that develops from an imbalance in the energy balance (EB). The lesion in the arcuate nucleus of the hypothalamus in rodents causes an imbalance in EB, biochemical and hormonal resulting in excess body fat storage in the body. The concentrated liquid extract of the residue of the fruit of the jabuticaba - Myrciaria cauliflora (ECJ) has become promising in the prevention/ treatment of chronic diseases, such as obesity, due to its bioactive compounds and antioxidant properties. The purpose of this work was to analyze the effects of ECJ (3%) on body mass, blood pressure, hematological and biochemical parameters in obese rats with monosodium glutamate (MSG). In the first days of life, the rats received subcutaneous injections in the posterior cervical region of MSG (4 mg/g) and control rats injected with isotonic saline (0.9%). After the weaning period (21 days), the animals were distributed in 4 experimental groups, treated or not for 60 days with the ECJ (3%) by gavage, group 1: control (CT); group 2: control treated with the extract (CT+E); group 3: monosodium glutamate (MSG); group 4: monosodium glutamate treated with the extract (MSG+E). In our study, rats that received injections of MSG with or without ECJ (3%) had: lower body weight gain and nasal/anal length, higher Lee index, and fat weight: retroperitoneal, inguinal and epididymal, lower cardiac index, lower liver and kidney weight, and lymphocytopenia. The rats that received only MSG showed an increase in mean blood pressure (MAP), increased levels of triglycerides (TG), and very-low-density lipoprotein (VLDL), leukopenia, the relative increase in monocytes, eosinophils and basophils. The MSG+E group demonstrated values of MAP, TG, VLDL, and leukocytes similar to those of animals CT+E and a lower level of low-density lipoprotein (LDL). There were no significant histological differences in cardiac tissue, total cholesterol, high-density lipoprotein, and in levels of tumor necrosis factor-alpha, interleukin 6, interleukin 4 and interleukin 10, in animals. From this, we concluded that the MSG was effective in inducing the obesity model and that the treatment with ECJ (3%) for 60 days demonstrated a beneficial protective action through PAM, TG, VLDL, and LDL altered by obesity.