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Efeito da orientação para perda de peso em pacientes inférteis com sobrepeso e obesidade
(Universidade Federal de Goiás, 2022-01-27)
Introduction: Obesity is considered a worldwide epidemic, being a serious public health problem. Overweight and obesity are characterized by the accumulation of body fat that poses a health risk. Several pathophysiological disorders are caused by obesity, especially in people with Body Mass Index (BMI) above 30 kg/m². It is increasingly common among women of childbearing age. Obese women are three times more likely to suffer from infertility than women with a normal body mass index. Objective: Evaluate the response to weight loss guidance in anthropometric parameters of obese and overweight infertile patients undergoing assisted fertilization treatment (high and low complexity). Methods: Retrospective cohort. A survey was carried out of a population of overweight and obese infertile patients one to two years after the first visit. In the first consultation at the assisted reproduction clinic (Human Reproduction Laboratory HC / UFG) as obese and overweight patients were instructed to lose weight and information that excess weight could decrease as chances of being successful in the treatment. As endocrine variables, estradiol, FSH, and LH were evaluated between obese and overweight patients in relation to normal weight patients. Proportions were compared using the chi-square test. Medians with the Mann-Whitney test. The H0 Rejection Level was 5%. Results: The age of the patients and the values of FSH, LH and estradiol were evaluated and paired, it was then verified that all presented p>0.05 after the adjustments. The age range of patients ranged from 21 to 40 years, with a mean of 35.59 ± 3.23 for the group with normal BMI and 35.78 ± 3.70dp for the group classified as overweight and obese. The mean weight in kg before and after orientation was 77.11±11.77 and 78.98±12.86 (p<0.0046). The mean BMI (kg/m²) before guidance was 29.69 ± 3.75dp and after guidance was 30.42 ± 4.32 (p<0.0038). Regarding ovulation, 31.6% of patients who lost weight did not ovulate compared to 20.0% of patients who gained weight. Patients who maintained their weight (16.7%) did not ovulate compared to 20.0% of patients who gained weight. Statistically non-significant difference. As for the endocrine variables, FSH, LH and estradiol, when comparing the population with normal weight with the population with overweight and obesity, no significant differences were found. Conclusions: There was a low percentage of weight loss in the patients, as only 37.5% achieved this goal. A greater number of patients gained or maintained their initial weight. Regarding ovulation, no significant associations were found when comparing patients who lost weight and those who gained weight, and also patients who maintained their weight compared to those who gained weight. As for the endocrine variables, in this study, the influence of obesity or overweight on these variables was not detected. The main diagnosis of infertility was bilateral tubal obstruction due to tubal ligation and other causes. Regarding the type of infertility, it was observed that cases of the primary type were the most frequent.
Análise dinâmica não linear de cascas de dupla curvatura
(Universidade Federal de Goiás, 2023-12-13)
In the literature, the analytical and semi-analytical formulations used for shell analysis are pri marily based on theories designed for shells parameterized by orthogonal surfaces. In this work, tensor theories, especially Koiter’s theory, capable of dealing with non-orthogonal surfaces as well, are employed for analyzing shells with double curvature: spherical panels, elliptical and hyperbolic paraboloids, and parabolic conoids. The shells, made of linear elastic material, are analyzed using a semi-analytical model derived from the Rayleigh-Ritz method. Due to the complexity of the geometry and boundary conditions of the analyzed shells – and consequen tly, the displacement fields – the constructed models require a significant number of degrees of freedom to achieve numerical convergence. Thus, two order-reduction techniques were used for shell analysis, the Proper Orthogonal Decomposition and the Spectral Submanifolds. The natural frequencies, vibration modes, non-linear static responses, and non-linear free and for ced vibrations of shallow and non-shallow doubly curved shells were determined. The results show that the tensor formulation is superior to the orthogonal formulations for shallow and non shallow shells. The order-reduction techniques used were effective in reducing computational effort and processing time, without compromising the results of the analyses, within the load and displacement limits of their formulations. The results contribute to the understanding of nonlinear phenomena present in these structures.
Avaliações em larga escala implementadas pela SEDUC GO: ações pedagógicas e orientações técnicas que subsidiaram a produção dos instrumentos da avaliação de matemática
(Universidade Federal de Goiás, 2021-11-25)
This work, entitled “Large-scale assessments implemented by Seduc GO: Pedagogical actions and technical guidelines that supported the production of Mathematics assessment instruments”, is linked to the research axis “Pedagogical practices for teaching and learning Science and Mathematics and the evaluation processes" referring to the research line "Teaching and Learning of Science and Mathematics" of the Graduate Program in Education in Science and Mathematics, at the Federal University of Goiás. It aims to analyze systemic evaluations (Diagnostic Evaluation and the Directed Sample Evaluation) of Mathematics applied by the state network of Goiás in the 5th year of Elementary School I, 9th year of Elementary School II and in the 3rd year of High School from 2011 to 2018, in order to understand and record the relevant milestones which comprised (i) the process of implementing these assessments, (ii) the criteria used to structure them and (iii) the technical elements related to the theoretical-methodological foundation adopted by the team of designers. For this, based on the assumptions of qualitative research and the theoretical framework of classroom assessment, school assessment and systems assessment, we investigated Diagnostic Assessment (2011-2014) and Directed Sample Assessment (2015 – 2018), the general guidelines that were sent to the applicator teacher, the instruments to help correct the tests and the circular letters sent by the State Department of Education of Goiás, among others. The paths taken during the work favored us to reflect and understand the objectives and origins of these evaluations. In addition, through this research, we were able to identify characteristics and technical elements related to the Mathematics items that made up these assessments and understand their correction dynamics, through the instruments that were sent by the department for this purpose.
Desenvolvimento de carreador lipídico nanoestruturado contendo filtro UV avobenzona
(Universidade Federal de Goiás, 2022-09-30)
Introduction: Avobenzone (AVB) is an organic filter, acting in the ultraviolet (UV) A spectrum. It is a cosmetic ingredient that presents photo-instability, impairing its photoprotective activity. For AVB photoprotection, its molecule must be in conformation, however, exposed to a UV photoisomerization it undergoes, passing to a keto form, which has no protection against UVA radiation. Objective: To develop and characterize a nanostructured lipid carrier (NCL) containing AVB and to evaluate its photostability. Methods: The High Performance Liquid Chromatography (HPLC) method was validated to evaluate the AVB. The AVB compatibility with the selected components was the premeans evaluation of thermal analysis of spectrogravimetry and Fourier transformed infrared (FT-IR) porscopy. AVB solubility was for 24 hours by temperature test, under temperature of 37°C, for 24 hours. Afterwards, the components for the composition of the recommended formulation were selected as reasons according to the literature. For the maintenance of the CLN, the method of inversion of phases with application of microfluidization was used. To characterize the performance of the tests: preliminary stability for 14 days, average stability and follow-up of the formulation, evaluation of polydispersity, 30 days, evaluation of pH parameters, particle size, index index (Pd) and content. The encapsulation efficiency (EE%) was performed by the indirect method. The photo stable study lasted 24 hours and consisted of the evaluation of the NLC containing AVB under UVA radiation. The surface of the nanoencapsulated skin surface, AV was projected for 24 hours, using the Franz interface. Results and discussions: the studies of definition of average size, corroborate for the definition of the components of the CLN, isopropyl myristate, 80 and span 85. After the conclusion of the white CLN, the results of size and PdI of 145.9 ± 57 were obtained. .32 nm and 0.196 ± 0.04, respectively. When an AVB was incorporated into the CLN, 135.77 ± 7.27 nm of mean size and 0.150 ± 0.09 of PdI were obtained. For EE%, the value of 72.82± 1.81% of asset encapsulation was generated. Subsequently, the capacity test was performed, to which the solubilized AVB test was presented and the solubilized AVB presentation of solubilized AVB was presented and tested in how much AVB sampled the sample not presented to exposure. The AVB, did not show permeation of clothes in the skin CLN, having its actions in the skin of the CLN, having its skin. Conclusion: Thermal studies will allow the proper selection of formulation constituents. The functional treatment system developed, with protected CLN photo treatment features, and CLN photo treatment features protective conditions, thus, face to face UV. As for its safety, it is seen that the AVB remained mostly retained in the stratum corneum, it did not present permeation to the skin.
Qualidade da assistência especializada a pessoas com diabetes mellitus e hipertensão arterial segundo o Chronic Care Model
(Universidade Federal de Goiás, 2022-04-27)
INTRODUCTION: Support for self-management of chronic conditions and health literacy are essential elements in the development of person-centered services. The use of integrated care models that focus on the person, and not just on the specific disease, represent a viable solution for effective care. The Chronic Care Model is a model that is based on the relationship between motivated and informed users and the proactive and prepared health team. However, there is evidence of gaps in the attention and care that should be provided in the care of chronic conditions, especially in hypertension and diabetes. OBJECTIVE: To characterize the quality of care provided and the health literacy conditions reported by people with arterial hypertension and diabetes mellitus in a secondary care service. METHODS: Crosssectional study, carried out in an outpatient clinic that is a reference in the care of arterial hypertension, in a large Brazilian center, where diabetes is prevalent morbidity. Eighty-two people with diabetes mellitus and arterial hypertension were evaluated, with a follow-up of at least five years and ten consultations. Sociodemographic and clinical data were obtained through a nursing consultation. The Patient Assessment of Care for Chronic Conditions - PACIC questionnaire was applied, with 20 questions and five scales. Higher scores (> 3.0) indicate a perception of greater involvement in self-management and support. Three scales from the Brazilian version of the Health Literacy Questionnaire - HLQ-Br were also used. The score of each scale indicates the person's strengths and weaknesses in relation to their health literacy. Internal consistency was evaluated; Mann-Whitney test, Spearman test and significance of 5% were applied. RESULTS: The mean age of the participants was 68.98±8.79 years, female (82.93%), with a median of 4 years of study (IQR 3 - 8). Most parents (70.73%) did not study. Less than half of the users had controlled values of glycated hemoglobin - HbA1c (34.15%) and blood pressure (36.59%). The Cronbach alpha of PACIC was 0.85 and that of HLQ-Br was 0.75. There was a positive correlation between the time of diagnosis of diabetes and HbA1c. The overall PACIC score was 3.4 (IQR 2.8-3.8) out of a high of 5.0. The highest score was evidenced on the scale of care/decision-making model (4.3) and the lowest on the scale of coordination of care/follow-up (2.8). Support for selfmanagement is assessed by the treatment adherence scores (3.0), problem-solving / follow-up contextualization (3.0), and goal setting (3.8). Those with ≥ 4 years of schooling had higher scores for Attention Coordination / Follow-up (p=0.039). Participants whose parents had some schooling had higher scores for Adherence to treatment (p=0.038), Coordination of care / Follow-up (p=0.042) and general PACIC (p=0.026). Lower scores were identified among participants who did not have HbA1c control, on the Goal Setting scale (p=0.003). Health literacy showed mean scores of 4.07 ± 0.87 on the Ability to interact with the team scale; 3.02±1.31 in Understanding the information and 2.84±1.25 in Finding good information. Male users had higher scores for interacting with professionals, finding information and understanding information (p=0.039, p=0.00 and p=0.003). Those with ≥ to 4 years of schooling had higher scores for Finding and Understanding information (p=0.002 and p< 0.001), as well as those whose parents had some schooling (p=0.036 and p=0.037). Those who were overweight had a higher score for Understanding the information (p= 0.040). There was a positive correlation between the time of diagnosis of diabetes and HbA1c and no correlation was identified between the general value of PACIC and the HLQ-Br scales. CONCLUSIONS: The quality of care was considered high according to the general PACIC, and moderate in terms of the person's participation in decision-making and the contextualization of the treatment plan. Weakness was identified in the dependence on other people to be able to access and understand written information, but the ease of involvement with professionals can favor the use of communication strategies to improve health self-management.