Doutorado em Biotecnologia e Biodiversidade - Rede Pró Centro-Oeste
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Item Múltiplos endpoints da toxicidade dos nanoplásticos de poliestireno e das nanopartículas de óxido de zinco em peixes e mamíferos(Universidade Federal de Goiás, 2021-10-20) Resende, Fernanda Neves Estrêla; Pereira, Paulo Sérgio; Pinto, Guilherme Malafaia; http://lattes.cnpq.br/7222293518573336; Pinto, Guilherme Malafaia; Rodrigues, Fernanda Postalli; Matos, Letícia Paiva de; Silva, Ives Charlie da; Oliveira, Vanessa Bezerra de MenezesThe toxicity of zinc oxide nanoparticles (ZnO NPs) and polystyrene nanoplastics (PS NaPs) has been demonstrated in different animal models. However, knowledge about the impact of these pollutants is incipient, even in terms of a combination of these pollutants. Thus, we aim to evalu-ate the effects of these nanomaterials in Swiss mice (Mus musculus) and grass carp (Ctenopharyn-godon idella) after individual exposure and in binary combination. It was investigated whether the short exposure (three days) to the environmentally relevant dose (760 µg/L) of the pollu-tants would be able to cause neurotoxic, biochemical, and genotoxic effects in animals. Our data reveal that although the exposures did not cause locomotor and anxiogenic or anxiolytic changes to animals exposed to pollutants, we observed some specific differences in behavioral tests. Fish exposed to PS NaPs showed a deficit in the response to the mirror test, both sepa-rately and in combination with nanoparticles. On the other hand, all treatments also induced inactivity in relation to alarm substances (paper #1). In mice, we could observe cognitive impair-ment in the object recognition test (individually). However, these parameters did not differ be-tween animals in the control group and those exposed to the binary combination of pollutants. On the other hand, exposures (individual and in combination) equitably induced damage to erythrocyte DNA. There was an increase in oxidative stress, especially in groups exposed to PS NaPs (in combination, or not, with nanoparticles). Although increased, the levels of antioxidants evaluated do not appear to be sufficient to inhibit the effects of treatment-induced free radical production (paper #2). Taken together, our studies confirm the toxicological potential of NPs ZnO and PS NaPs in the models studied and encourage new studies to further investigate the factors that elucidate the absence of additive or synergistic effects arising from combined expo-sure to pollutants.