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Navegando Programa de Pós-graduação em Nutrição e Saúde por Por Orientador "Cominetti, Cristiane"
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Item Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular(Universidade Federal de Goiás, 2015-03-20) Alves, Maira Chiquito; Horst, Maria Aderuza; Cominetti, Cristiane; http://lattes.cnpq.br/3143023553465749; Silva, Daniela de Melo e; Botelho, Patrícia Borges; Cominetti, CristianeTo verify the relationship between the polymorphisms rs18011282 in PPAR-gamma gene and rs429358 + rs7412 in apolipoprotein E gene and lipid profile of adolescents under cardiovascular risk factors. Material and methods: The study sample was composed of 115 adolescents aged 10-19 years, which presented cardiovascular risk factors. The students were evaluated regarding socioeconomic, anthropometric, biochemical, genetic and dietetic variables. ANOVA or Kruskal-Wallis tests were used in the analysis of ungrouped genotypes, while Student’s t-test or Mann-Whitney test were applied to the analysis of the grouped genotypes. Results: The overweight adolescents presented lower HDL-c concentrations (p=0.0016). Those carrying PPAR-gamma Ala allele showed higher serum TAG (p=0.0423) and VLDL-c (p=0.0410) levels when compared to those carrying the Pro allele. For the apolipoprotein E gene polymorphism, it was observed a tendency of higher TAG (p=0.0712) and VLDL-c (p=0.0758) levels in the adolescents carrying the E4 allele when compared to those who did not carry this allele. Conclusion: The polymorphisms PPAR-gama rs18011282 and apolipoprotein E rs429358 + rs7412 seem to be related to the development of lipid profile alterations in adolescents.Item Relações entre polimorfismos no gene da apolipoproteína e, perfil lipídico e consumo alimentar de adultos com a síndrome do obeso eutrófico(Universidade Federal de Goiás, 2016-05-03) Franco, Lana Pacheco; Horst, Maria Aderuza; http://lattes.cnpq.br/4145824009736834; Cominetti, Cristiane; http://lattes.cnpq.br/3143023553465749; Botelho, Patrícia Borges; Furlaneto, Silvia Maria Salem Izacc; Cominetti, CristianeThis study aimed to assess whether polymorphisms in the apolipoprotein E gene and food consumption are related to lipid profile of adults with Normal-Weight Obesity Syndrome. Methodology: this was an analytical cross-sectional study, including adults with Normal-Weight Obesity Syndrome. Socioeconomic, health and lifestyle questionnaires were administered. Anthropometric variables, body composition and blood pressure were evaluated. Dietary intake, lipid profile and genotyping of polymorphisms rs7412 and rs429358 in the apolipoprotein E gene were evaluated. Results: from the 115 individuals, 72.2% were women. The median age was 22.6 years (21.4 – 25.2). Only 6.0% of women and no man had increased waist circumference. No women and 6.2% of men had changes in blood pressure. When traditional lipid profile was assessed, 52.5% had dyslipidemia. When apolipoprotein concentrations were included, the prevalence was 73.0%. There was a positive relationship between the presence of allele ε2 and apolipoprotein A1 levels (ε2ε3 versus ε3ε3: β = 21.3; 95% CI = 4.2 to 38.3; p = 0.015) and between ε4 allele and apolipoprotein B (ε4 versus ε2: β = 14.8; 95% CI = 0.08 a 29.5; p = 0.049 and ε4 versus ε3: β = 9.1; 95% CI = 0.6 a 17.6; p = 0.036). Carriers of ε2 allele had 81% less chance of presenting dyslipidemia compared to ε3ε3 individuals (OR = 0.2; 95% CI = 0,04 a 0,8; p = 0.027). Associations between body fat distribution and lipid profile and between food consumption and lipid profile were observed and differed among genotypes. Conclusion: both polymorphisms in the apolipoprotein E gene and the food consumption were associated with lipid profile of adults with Normal-Weight Obese Syndrome. This was the first study to describe the apolipoprotein E genotype and to analyze relationships between genetic profile, food intake and lipid profile of subjects with Normal-Weight Obesity Syndrome.Item Prevalência de fatores de risco cardiovascular em cadetes da academia da força aérea brasileira(Universidade Federal de Goiás, 2013-05-29) Hilgenberg, Fernanda Elisabete; Silveira, Érika Aparecida da; Cominetti, Cristiane; http://lattes.cnpq.br/3143023553465749; Cominetti, Cristiane; Sousa, Ana Luiza Lima; Monego, Estelamaris Tronco; Peixoto, Maria do Rosário Gondim; Freitas, Ana Tereza Vaz de SouzaModifications in contemporary lifestyles reflect negatively on the individuals’ health status and are associated with the incidence of cardiovascular risk factors (CVRF), and hence with the genesis of cardiovascular disease (CVD). Currently, 31.3% of deaths in Brazil occur in consequence of CVD. It is observed that CVRF have been affecting the younger population, even the Brazilian military. Therefore, the aim of this study was to determine the prevalence of some CVRF in cadets from the Brazilian Air Force Academy (AFA). It was a cross-sectional observational study that evaluated 166 cadets from the 1st to the 4th year of the AFA. Data collection was performed at the AFA’s Clinic of Nutrition from the Health Subdivision , with measures of anthropometric data: weight, height, body mass index, waist circumference and skinfold thickness. Blood was collected for lipid profile and serum glucose evaluation. Blood pressure was measured at rest. Three-day food records were collected and analyzed using the software Avanutri®. Lifestyle was assessed with a questionnaire which included physical activity and smoking habit data. The Pearson Chi-Square or Fisher's exact tests were used to assess the associations between CVRF, gender and the year of entrance at the AFA. The food consumption data were adjusted to the energy by the residual method. The significance level of 5% was adopted as standard. The study was submitted to the Ethics Committee of Federal University of Goias and approved under Protocol n°. 189/12. The sample was composed of 147 men and 19 women, mean (± SD) age of 21.5 ± 1.2 and 21.6 ± 0.9 years, respectively. It was verified that 29.7% of men and 16.7% of women were overweight or obese. The prevalence of hypertension among men was 15.2%. The lipid profile revealed that 50.7% of the cadets had hypercholesterolemia, 24.3% had elevated LDL-c and 11.2%, low HDL-c. There was a significant association between the time spent at AFA and low HDL-c. The prevalence of low HDL-c was statistically higher among the cadets from the 1st and 2nd years. Food consumption data showed that 58.7% of men and 50% of women had an intake above the daily requirement. There was a high prevalence of saturated fats (87.2%) and cholesterol (42.7%) intake in both genders. No cadet reached the recommendations for monounsaturated and polyunsaturated fat intake and the inadequate intake of dietary fiber was reported in 92.7% of them. It was verified that the young military personnel are exposed to CVRF in a similar manner to young civilians. These results are relevant in order to create and install multidisciplinary approaches aiming at reducing the risk of CVD in the early stages of adulthood, thereby ensuring a better quality of life and reduction of cardiovascular health problems in the long term of the future officers of Brazilian Air Force.Item Padrões alimentares de adolescentes de uma escola pública de Goiânia(Universidade Federal de Goiás, 2017-02-22) Lobo, Ana Moraes; Cominetti, Cristiane; http://lattes.cnpq.br/3143023553465749; Cominetti, Cristiane; Marchioni, Dirce Maria Lobo; Peixoto, Maria do Rosário Gondim; Marques, Rosana de Morais Borges; Hadler, Maria Claret Costa MonteiroObjective: to identify dietary patterns of adolescents from a public school in Goiânia and to determine the associated factors. Material and methods: cross-sectional study with 446 adolescents aged 10-19 years, enrolled in a public school in Goiânia, Goiás. Dietary intake was assessed by a usual food recall. Principal component factor analysis with Varimax rotation was used to identify dietary patterns. Factor scores were calculated and then used in multiple linear regression to evaluate socioeconomic, anthropometric and lifestyle factors associated with the patterns. Results: four dietary patterns were identified and together explained 38.8% of the food consumption total variance. These patterns were denominated: 1) traditional meal (characterized by cereals and roots, legumes, meats, vegetables and sugar-sweetened beverages), 2) traditional snack (which included farinaceous snacks, butter and margarine, dairy and sweets, and was inversely associated with processed meat consumption), 3) processed snacks (processed meat, yellow cheese and farinaceous snacks), and 4) junk food (composed by candies, fatty snacks, sugar-sweetened beverages and pastas and inversely associated with intake of fruits). The pattern “traditional meal” was inversely associated with body mass index and female sex. The pattern “traditional snack” was inversely associated with body mass index and positively associated with greater time sitting at the weekend. The pattern “junk food” was associated positively with the greater daily time in front of television. Only this latter pattern did not present an inverse association with commuting to school by car. Conclusion: adolescents’ dietary patterns were associated with anthropometric and lifestyle variables, so that a diet based on traditional Brazilian foods is recommended because it seems to favor lower body mass indexes.Item Metabolismo da homocisteína e perfil lipídico de adolescentes com fatores de risco cardiovascular: relações com polimorfismos no gene da metilenotetra-hidrofolato redutase(Universidade Federal de Goiás, 2015-03-27) Morais, Carla Cristina de; Horst, Maria Aderuza; http://lattes.cnpq.br/4145824009736834; Cominetti, Cristiane; http://lattes.cnpq.br/3143023553465749; Cominetti, Cristiane; Izacc, Sílvia Maria Salem; Botelho, Patrícia BorgesObjective: to investigate the prevalence of alterations in homocysteinemia, lipid profile and vitamins B6, B12 and folic acid concentrations, as well as the possible relationships among C677T and A1298C polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene and blood concentrations of these biomarkers in adolescents with cardiovascular risk factors. Material and Methods: cross-sectional study with adolescents (10-19 years old) from a public school in Goiânia, Goiás. Screening was performed with 454 students in this age group. Those who were overweight, or presented risk factors associated with family history, or had been previously diagnosed with dyslipidemia were recruited, totaling a final sample of 115 individuals. Blood concentrations of homocysteine, vitamin B6 and vitamin B12, folic acid, oxidized low density lipoprotein (ox-LDL) and lipids were analyzed. The sample was stratified according to tertiles of plasma homocysteine concentrations. Genotyping of the above mentioned polymorphisms was performed. Analysis of differences between means was performed using Student’s t test, Mann Whitney, ANOVA or Kruskal-Wallis’s test. Correlations among variables were evaluated with the Pearson’s correlation or Spearman’s test. Results: hyperhomocysteinemia was observed in 19.1% of the sample and alterations in prevalence of alterations in the lipid profile were 30.4%, with 48.0% to high-density lipoprotein, and vitamin B6 deficiency was 23, 5%. Individuals in the highest tertile for homocysteine showed blood concentrations of folic acid and HDL-c higher compared to those of the middle and lower tertile, and waist circumference greater than in those of the lower tertile. There were no significant differences in anthropometric and biochemical variables when analyzed according to the three possible genotypes realtives to the C677T and A1298C polymorphisms. However, when heterozygous and homozygous for the variant alleles for C677T polymorphism were grouped, carriers of the variant ones showed higher plasma concentrations of oxidized low density lipoprotein (p < 0.01) and vitamin B6 plasma levels (p < 0.02). Conclusion: Despite the high prevalence of hyperhomocysteinemia, it was not observed it was not observed relationship of C677T and A1298C polymorphisms with plasma concentrations of homocysteine. However, the results of the study revealed the influence of MTHFR C677T genotype on vitamin B6 and oxidized low density lipoprotein levels.Item Polimorfismo no gene que codifica a perilipina 1 e suas relações com consumo alimentar, composição corporal e glicemia de indivíduos com síndrome do obeso eutrófico(Universidade Federal de Goiás, 2016-05-31) Silveira, Amanda Gonçalves Zardini; Horst, Maria Aderuza; http://lattes.cnpq.br/4145824009736834; Cominetti, Cristiane; http://lattes.cnpq.br/3143023553465749; Izacc, Sílvia Maria Salem; Marques, Rosana de Morais Borges; Cominetti, CristianeTo verify whether the polymorphism 11482G> A (rs894160) in PLIN1 gene has influence on food intake, body composition and glucose and insulin metabolism in individuals with Normal-Weight Obesity Syndrome. Methods: Cross-sectional study conducted at the Faculty of Nutrition of Federal University of Goiás (FANUT / UFG) with 116 individuals aged 20 to 59, with eutrophic body mass index (between 18.50 and 24.99 kg/m²) and high body fat percentage (20% for men and 30% for women) measured by dual-energy X-ray absorptiometry (DEXA). The polymorphism 11482G> A (rs894160) in PLIN1 gene was genotyped using qPCR Taqman® system. Fasting glucose and insulin, as well as glycosylated hemoglobin (HbA1c) were evaluated through classical methodology. QUICKI, HOMA-IR and HOMA-beta indexes were calculated. Food intake was evaluated from three 24 h food records, including a weekend day. The interaction between macronutrients intake and the SNP was determined by regression model and adjusted for potential confounders. Analyzes of mean differences were performed using Student’s t test, Mann Whitney, ANOVA or Kruskal-Wallis. P<0.05 was considered significant. Results: 27.4% (n=32) of the sample were male and the median age (interquartile range) was 22.5 (20-50) years. Regarding the SNP, 56.0% (n = 65) carried two wild alleles, 38.8% (n = 45) were heterozygous and 5.2% (n = 6), carried two variant alleles. We did not verify statistical differences in biochemical and anthropometric biomarkers when subjects were separated according to genotype. Intake of carbohydrates and saturated fat, as well as the saturated fat:carbohydrates ratio were dichotomized into high and low according to the median intake of the sample (241.15 g; 29.71 g and 0.6 g, respectively). Males who carried the variant allele had lower waist circumference only when carbohydrate intake was higher than the median. They also presented lower weight and waist circumference when saturated fat consumption and saturated fat:carbohydrates ratio were low. Conclusion: The polymorphism PLIN1 11482G>A might modulate responses in anthropometric biomarkers in males with Normal-Weight Obesity depending on dietary macronutrient composition.