Obtenção de formulações fitocosméticas com atividade fotoprotetora a partir de pterodon sp. vogel fabaceae (sucupira)

Abstract

The use of natural products photoprotective cosmetic formulations have attracted consumers. This study aimed to get formulations with sunscreen and antioxidant activity, from the merger of the oil and hydroalcoholic extract of Pterodon sp. in semi solid formulations (Focus Gel®, LANETTE®, Polowax®) containing chemical filter Eusolex 2292®. Initially it was held potential of the evaluation study sunscreen with oil resin Pterodon sp. incorporated at a concentration of 15% in the formulation containing 0.06% of chemical filter Eusolex 2292. Subsequently followed investigations using the hydroalcoholic extract of Pterodon sp. (EHS) obtained by water bath under reflux at 50 ° C. Determined the sun protection factor extract solubilized in absolute ethanol and when incorporated in semi-solid formulations (Focus Gel®, LANETTE®, Polowax®) with 0.01% Eusolex 2292. This extract was characterized chemically-evaluating physical parameters density, solid content, moisture content, chromatographic profiles and determination of antioxidant activity by the methods of DPPH and FRAP. Finally we conducted a preliminary stability study only formulations containing extract, which were stable against exposure to extremes of freezing and thawing and thermal stress, with statistical comparison (p <0.05) in all evaluated parameters (pH , density, viscosity, electrical conductivity and FPS). The formulation containing SPF results Pterodon sp oil. was obtained FPS> 5.0, formulation containing the chemical filter FPS> 6.0 and formulation containing oil and chemical filter FPS> 12.0. For formulations containing extract incorporated in the bases (Focus Gel®, LANETTE®, Polowax®) were respectively found FPS 9.44 ± 0.508, 14.72 ± 0.304, 14.22 ± 0.503 and formulations containing chemical filter presented FPS of 10.52 ± 0.676, 8.75 ± 0.04, 8.18 ± 0.172 and formulations containing chemical extract and filter was obtained FPS of 27.74 ± 0.756, 24.77 ± 0.613, 23.87 ± 0.259 respectively. The data from the characterization of the extract were 0.910 ± 0.003 density, pH 6.05 ± 0.456, solids 9.73 ± 0.04, moisture content 92.97% ± 0.568, chromatographic profile for CCD indicative of the presence of flavonoids and phenolic acids. It was possible to verify that the SPF values were maintained within 30 days. It was determined the antioxidant activity by the methods of DPPH and FRAP and EC50 values were found 19.3 ± 1.5 uL / mL and 14 880 uM / mL. It was first confirmed the FPS additive effect in formulations with oil and Pterodon sp extract. in semisolid formulations. The analysis allowed confirming the EHS antioxidant activity, tending towards fotoquimioprotetora activity after the preliminary stability study confirmed the achievement of stable formulations. It concludes that the EHS has potential for the development of photoprotective cosmetic formulations.