Citrato de rodio (II): síntese, caracterização, adsorção em nanopartículas de maguemita e preparação de fluidos magnéticos
dc.contributor.advisor1 | Souza, Aparecido Ribeiro de | |
dc.contributor.advisor1Lattes | http://lattes.cnpq.br/7884708272070266 | por |
dc.creator | Nunes, Eloiza da Silva | |
dc.creator.Lattes | http://lattes.cnpq.br/4019603533072368 | por |
dc.date.accessioned | 2014-08-22T11:23:26Z | |
dc.date.issued | 2010-03-10 | |
dc.description.abstract | In this work are described the synthesis and characterization of dinuclear rhodium(II) citrate, adsorption study in maghemite nanoparticles, and preparation of nanoparticles-modified based magnetic fluids. Rhodium(II) citrate has significant antitumor activity being promissory to cancer chemotherapy. Due to the existence of free functional groups in its molecular structure this complex has capacity to functionalize iron oxide nanoparticles to produce drug-particles formulations. The modified nanoparticles show features of biocompatibility suitable to use the system in medical applications. Rhodium(II) citrate was synthesized by an exchange reaction of trifluoroacetate ligands from the precursor rhodium(II) trifluoroacetate by citrate ligands. The products were characterized by C and H elemental and thermogravimetric analysis, mass spectrometry, and infrared, UV/visible and 13C nuclear magnetic resonance spectroscopy. The results are consistent with the formation of dinuclear structure characteristic for rhodium(II) carboxylates. Changing the synthesis conditions were obtained products with stoichiometries [Rh2(H2cit)2(H2O)4] and [Rh2(H2cit)4(H2O)2]. The results and compounds solubility observations suggest that the first one occur as a coordination polymer. The second one showed composition e solubility behavior consistent with the formation of monomeric units. Maghemite nanoparticles with size mean between 5 and 7 nm were obtained through alkaline coprecipitation of Fe2+ and Fe3+ ions with further oxidation with oxygen gas. The solids were characterized by X-ray difratometry and the Scherrer relation was use to calculate the crystallite size mean. Adsorption experimental data were adjusted to Langmuir model and linear coefficients obtained, R2, were greater than 0,99. Functionalized nanoparticles were dispersed into water producing a stable colloid. Dispersion s characterization was performed by absorbance, zeta potential, and hydrodynamic diameter measurements. Surface properties and colloidal behavior of functionalized nanoparticles are much affected by adsorbed species. The colloidal stability of the magnetic fluids is dependent on the adsorbed amounts of rhodium(II) citrate and pH. When the adsorbed amount of rhodium(II) citrate is next to saturation, the magnetic fluids are stable in pH over 3 and show hydrodynamic diameter around 60 nm. Fluids colloidal stability is preserved against physiologic saline solution, PBS buffer, and fetal bovine serum over a period of 30 days. | eng |
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dc.description.resumo | Neste trabalho estão descritos a síntese e a caracterização do complexo dimérico citrato de ródio(II), estudo de sua adsorção em nanopartículas de maghemita e a preparação de fluidos magnéticos á base de nanopartículas modificadas com o complexo. O citrato de ródio (II) apresenta significante atividade antitumor sendo promissor para aplicação na quimioterapia do câncer. Devido à existência de grupos funcionais livres em sua estrutura molecular esse complexo possui capacidade de funcionalizar nanopartículas de óxidos de ferro para produzir formulações droga-partícula. As nanopartículas modificadas apresentam características de biocompatibilidade adequadas para utilização do sistema em aplicações médicas. O citrato de ródio(II) foi sintetizado via reação de troca de ligantes trifluoroacetato do precursor trifluoroacetato de ródio(II) por citrato. Os produtos foram caracterizados por análise elementar de C e H e termogravimétrica, espectrometria de massas e espectroscopia nas regiões do UV/visível e infravermelho e ressonância magnética nuclear de 13C. Os resultados são consistentes com a formação da estrutura dimérica. Variando-se as condições de síntese pode-se obter produtos com estequiometrias [Rh2(H2cit)2(H2O)4] e [Rh2(H2cit)4(H2O)2]. Os resultados somados às observações sobre a solubilidade dos compostos sugerem que o primeiro ocorre como um polímero de coordenação. O segundo composto apresentou características de composição e solubilidade coerente com a formação de unidades dimetálicas monoméricas. Foram obtidas nanopartículas de maghemita com diâmetros entre 5 e 7 nm através do método de coprecipitação de íons Fe2+ e Fe3+ em meio alcalino com posterior oxidação com oxigênio gasoso. Os sólidos foram caracterizados por difratometria de raios-X e o diâmetro de cristalito calculado pela equação de Scherrer. Os dados experimentais de adsorção de citrato de ródio(II) em maghemita foram ajustados ao modelo de Langmuir sendo obtido coeficiente de regressão linear, R2, maior que 0,99. As nanopartículas funcionalizadas foram dispersas em água obtendo-se um colóide estável. As dispersões foram caracterizadas por medidas de absorvância, potencial zeta e de diâmetro hidrodinâmico. As propriedades de superfície bem como o comportamento coloidal das nanopartículas funcionalizadas são influenciadas pelas espécies adsorvidas. A estabilidade coloidal dos sóis obtidos é dependente das quantidades de citrato de ródio(II) adsorvida e do pH. Quando a quantidade de citrato de ródio adsorvida é próxima da capacidade de adsorção, os fluidos magnéticos obtidos apresentam estáveis em pH acima de 3 com diâmetros hidrodinâmicos próximos de 60 nm. A estabilidade coloidal dos fluidos obtidos é preservada frente a soluções de soro fisiológico, tampão PBS e soro fetal bovino por períodos superiores a 30 dias. | por |
dc.format | application/pdf | * |
dc.identifier.citation | NUNES, Eloiza da Silva. Citrato de rodio (II): síntese, caracterização, adsorção em nanopartículas de maguemita e preparação de fluidos magnéticos. 2010. 121 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás,Goiânia, 2010. | por |
dc.identifier.uri | http://repositorio.bc.ufg.br/tede/handle/tde/2920 | |
dc.language | por | por |
dc.publisher | Universidade Federal de Goiás | por |
dc.publisher.country | Brasil | por |
dc.publisher.department | Instituto de Química - IQ (RG) | por |
dc.publisher.initials | UFG | por |
dc.publisher.program | Programa de Pós-graduação em Química (IQ) | por |
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Fe2O3 nanoparticles: a robust and magnetically recoverable catalyst for threecomponent coupling of aldehyde, alkyne and amine. Green Chemistry, v. 12, p. 570-573, 2010. ZYNGIER, S.; KIMURA, E.; NAJJAR, R. Antitumor effects of rhodium(II) citrate in mice bearing ehrlich tumors. Brazilian Journal of Medical and Biological Research, v. 22, p. 397-401, 1989. ZHOU, Z. H.; HOU, S. Y.; CAO, Z. X.; TSAI, K. R.; CHOW, Y. L. Syntheses, spectroscopies and structures of molybdenum(VI) complexes with homocitrate. Inorganic Chemistry, v. 45, p. 8447-8451, 2006. ZHU, Y.; WU, Q. Synthesis of magnetite nanoparticles by precipitation with forced mixing. Journal of Nanoparticle Research, v. 1, p.393-396, | por |
dc.rights | Acesso aberto | por |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Nanopartículas magnéticas | por |
dc.subject | Óxido de ferro | por |
dc.subject | Carboxilatos de ródio (II) | por |
dc.subject | Agente antitumor | por |
dc.subject | Estabilidade coloidal | por |
dc.subject | Magnetic nanoparticles | eng |
dc.subject | Iron oxide | eng |
dc.subject | Rhodium(II) carboxylates | eng |
dc.subject | Antitumor agents | eng |
dc.subject.cnpq | CIENCIAS EXATAS E DA TERRA::QUIMICA | por |
dc.thumbnail.url | http://repositorio.bc.ufg.br/tede/retrieve/6495/Disserta%c3%a7%c3%a3o_Eloiza%20da%20Silva%20Nunes.pdf.jpg | * |
dc.title | Citrato de rodio (II): síntese, caracterização, adsorção em nanopartículas de maguemita e preparação de fluidos magnéticos | por |
dc.title.alternative | Rhodium(II) citrate: synthesis, characterization, adsorption on maghemita nanoparticles, and preparation magnetic fluids | eng |
dc.type | Dissertação | por |
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