Estudo de associação ampla do genoma bovino para lactação ajustada em 305 dias em girolando
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2015-10-19
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Universidade Federal de Goiás
Resumo
Genomic selection in a dairy cattle breeding is a new strategy in national livestock.
Genome wide association study (GWAS) is known as a strategy that involve the use
of molecular markers panels distributed throughout the genome which are selected
for the identification of chromosomal regions that are important for the interest traits.
The aim of this study was apply the GWAS strategy for 305-day milk yield in
Girolando cows. We did the genotype from 404 Girolando and after quality control
analysis remained 337 individuals and 45.622 markers. The GWAS analysis resulted
in 52 SNPs associated to 305-day milk yield. Of these, 23 SNPs were linked to
Known genes and only 3 SNPs were linked to NUB1, SLC24A2 and DGAT1 genes
that already were associated with cattle lactation. The other SNPs have no
relationships described in the cattle lactation literature. In addition, the milk
production QTL analysis resulted in 52 SNPs and 14 genes linked or close to 1Mb of
the SNP marker. The ARS-BFGL-NGS-414 SNP on BTA19 at 47.9Mbp is located
near to GH1 gene. This gene is commonly accepted as causal gene for Quantitative
Character Locus of milk production mainly affecting the yield in liters and solid milk
components. Thus, our data suggest that NUB1 and SLC24A2 genes could be
considered as candidate genes to understand the milk production in Girolando breed.
Like this DGAT1 and GH1 genes are valuable predictive markers to be added to
genomic selection of dairy cattle in breeding program.
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CRUZ A. S. Estudo de associação ampla do genoma bovino para lactação ajustada em 305 dias em girolando. 2015. 106 f. Tese (Doutorado em Biologia) - Universidade Federal de Goiás, Goiânia, 2015.