Estudo Fitoquímico das Folhas de Psychotria hoffmannseggiana Roem. & Schult (Rubiaceae)
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2014-04-11
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Universidade Federal de Goiás
Resumo
Psychotria hoffmannseggiana (Wild. ex Roem. & Schult.) Müll. Arg. is
a subshrub of the Rubiaceae family, which belongs to the genus Psychotria
L. and to the subgenus Heteropsychotria. In this genus there is several indole
alkaloids, recognized by their many bioactive properties. Furthermore, these
alkaloids are used as chemotaxonomic markers in the classification and
delimitation of the Psychotria genus. Up to this moment, no phytochemical
study has been reported for the P. hoffmannseggiana species. Therefore, in
the continuous searching for secondary metabolites, the crude ethanol
extract (PHF-EB) from P. hoffmannseggiana leaves has been submitted to
an acid-base fractionation, and the resultant fractions were subject to column
chromatography. The methyl sinapate (PH-01) and the isoscopoletin (PH-02)
were identified from the acid chloroform extract (PHFA-C). In the basic
chloroform extract (PHFB-C), three indole alkaloids were isolated and
identified: harman (PH-03), N-methyl-1,2,3,4-tetrahydro--carboline (PH-04),
N-methyltryptamine (PH-05); as well as one polyindolic alkaloid, (+)chimonantine
(PH-06). Besides, a great amount of monoterpenic indole
alkaloid, the strictosidinic acid (PH-07), was isolated from the basic nbutanolic
extract and ethyl acetate, PHFB-n-BuOH and PHFB-AcOEt,
respectively. The -ethylglucose (PH-08) was isolated from the basic nbutanolic
extract (PHFB-n-BuOH). The evaluation of the antioxidant activity
of the extracts PHF-EB, PHFA-C, PHFB-C, PHFB-AcOEt and n-PHFB-nBuOH
showed a 50% inhibition of DPPH radical at concentrations of 176,58
± 1 35, 105.47 ± 0.88, 77.60 ± 0.36, 191.30 ± 0.68 and 271.96 ± 0.57 g.mL1,
respectively.
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NAVES, Raquel Ferreira. Estudo Fitoquímico das Folhas de Psychotria hoffmannseggiana Roem. & Schult (Rubiaceae). 2014. 212 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Goiânia, 2014.