Efeito neuroprotetor da inibição do transportador de glicina do tipo 1 em modelos animais de dano estriatal
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2022-12-16
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Universidade Federal de Goiás
Resumo
The striatum is a region of the brain associated with motor control, with
changes in its function associated with neurodegenerative diseases such as
Parkinson's and Huntington's. Although several factors are related to the
neurodegeneration process in these diseases, the phenomenon of excitotoxicity and
excessive stimulation of NMDA receptors (NMDAR) is a common point between them.
An approach to prevent excitotoxicity is associated with the blockade of GlyT-1, which
promotes the increase of glycine in the synaptic cleft, promoting a profound
neuromodulation process. Based on this evidence, the objective of this work was to
evaluate the effect of pretreatment with a type 1 glycine transporter inhibitor (NFPS) in
animal models of Parkinson's disease (PD) and Huntington's disease (HD). Open field
tests, cylinder test, rotarod and apomorphine-induced rotation tests were used to
monitor motor changes in the experimental models. Western Blotting technique was
performed to evaluate protein expression upon treatment with NFPS. The results
suggest a neuroprotective effect, by preventing a reduction in movement, reducing
striatal damage, and increasing the expression of proteins related to cell survival.
Taken together, our data suggest that GlyT-1 inhibition has neuroprotective potential
for striatal lesions associated with HD and PD.
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RIBEIRO, Raul I. Efeito neuroprotetor da inibição do transportador de glicina do tipo 1 em modelos animais de dano estriatal. 2022. 71 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de Goiás, Goiânia, 2022.