Alterações dos parâmetros de comportamento de ratos tratados com peptídeo rico em prolina da serpente Bothrops jararaca, Bj-PRO-7a
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2018-05-16
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Universidade Federal de Goiás
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The Bj-PRO-7a, a heptapeptide isolated and identified from Bothrops jararaca (Bj) venom, evoke
potent therapeutic effects, as antihypertensive effect, natriuretic and diuretic effects, promotion of
angiogenisis and vasodilatation. The effects of heptapeptide are independent of Angiotensin
Converting Inhibitor (ACE), possibly dependent of Muscarinic Receptors subtype 1 (M1R)
activation and oxido nitric pathways. Also, the Bj-PRO-7a actions upon central nervous system
still need to be evaluated. Thus, the aims of this study were: i) to assess the effects of acute
administration of Bj-PRO-7a upon behavior; ii) to reveal mechanisms involved in the effects of Bj-
PRO-7a upon locomotion/exploration, anxiety and depression-like behaviors. For this purpose,
adult male Wistar (WT) and Spontaneous Hypertensive Rats (SHRs) (300-380 g) received i.p.
injections of Vehicle (NaCl 0.9%), Diazepam (2 mg/kg), Imipramine (15 mg/kg), Bj-PRO-7a (71,
213 or 426 nmol/kg), Pirenzepine (852 nmol/kg), α-metil-DL-tirosina (200 mg/kg) or
Chlorpromazine (2 mg/kg) and were placed in the Elevated Plus Maze (EPM), Open Field (OF)
and Forced Swimming (FS) tests. The heptapeptide promoted anxiolytic and antidepressantlike
effects and increased the locomotion/exploration. These effects of Bj-PRO-7a seem to be strongly
dependent on activation of M1R, catecholaminergic paths and dopaminergic receptors.
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TURONES, L. C. Alterações dos parâmetros de comportamento de ratos tratados com peptídeo rico em prolina da serpente Bothrops jararaca, Bj-PRO-7a. 2018. 70 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, Goiânia, 2018.