Avaliação molecular dos polimorfismos genéticos na performance motora de atletas de futebol
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2019-06-28
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Universidade Federal de Goiás
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Several genes have been identified as critical in athletic performance. The angiotensin-
converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been related to
improvements in performance and exercise duration. However, there are large
divergences among the studies with on the influence of ACE I/D polymorphism results for
physical performance. Other studies have demonstrated that strenuous exercise generally
overloads the endogenous antioxidant system’s capacity, leading to oxidative damage to
muscles and other tissues in athletes. Moreover, few studies reported significant
associations between Glutathione S-Transferases (GST) deletion polymorphisms and
resistance performance in athletes. This first study on the central Brazilian population
aimed to characterize the effects of ACE I/D and GST deletion polymorphisms on young
soccer players. We investigated 65 soccer players from the Under-20 (18 to 20 years old)
soccer teams and 60 non-athletes in a case-control study. All subjects had their physical
performance investigated through the Running-based Anaerobic Sprint Test (RAST).
Genotyping was performed using real-time Polymerase Chain Reaction. We found that
the I/D genotype was significantly more frequent in athletes compared with the non-
athletes (p=0.01). Individuals with the ID and DD genotypes had an approximately 3.13-
fold and 4.37-fold increase in strength and power-orientated performance, respectively.
The DD genotype in athletes presented results considered as excellent to good when
compared with non-athletes for RAST test. For the association of the GST deletion
polymorphisms and RAST test, there was no influence in the athletic performance. Most
importantly, we described the associations between ACE I/D polymorphism and athletic
performance. In this study, we found that GST polymorphisms indicated no associations
for the risk of oxidative damage to the muscle. Our findings may help to select young
players with the most favorable genetic potential to succeed as soccer athletes.
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MENEZES, W. C. F. Avaliação molecular dos polimorfismos genéticos na performance motora de atletas de futebol. 2019. 80 f. Dissertação (Mestrado em Assistência e Avaliação em Saúde) - Universidade Federal de Goiás, Goiânia, 2019.