Avaliação molecular dos polimorfismos genéticos na performance motora de atletas de futebol

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Universidade Federal de Goiás


Several genes have been identified as critical in athletic performance. The angiotensin- converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been related to improvements in performance and exercise duration. However, there are large divergences among the studies with on the influence of ACE I/D polymorphism results for physical performance. Other studies have demonstrated that strenuous exercise generally overloads the endogenous antioxidant system’s capacity, leading to oxidative damage to muscles and other tissues in athletes. Moreover, few studies reported significant associations between Glutathione S-Transferases (GST) deletion polymorphisms and resistance performance in athletes. This first study on the central Brazilian population aimed to characterize the effects of ACE I/D and GST deletion polymorphisms on young soccer players. We investigated 65 soccer players from the Under-20 (18 to 20 years old) soccer teams and 60 non-athletes in a case-control study. All subjects had their physical performance investigated through the Running-based Anaerobic Sprint Test (RAST). Genotyping was performed using real-time Polymerase Chain Reaction. We found that the I/D genotype was significantly more frequent in athletes compared with the non- athletes (p=0.01). Individuals with the ID and DD genotypes had an approximately 3.13- fold and 4.37-fold increase in strength and power-orientated performance, respectively. The DD genotype in athletes presented results considered as excellent to good when compared with non-athletes for RAST test. For the association of the GST deletion polymorphisms and RAST test, there was no influence in the athletic performance. Most importantly, we described the associations between ACE I/D polymorphism and athletic performance. In this study, we found that GST polymorphisms indicated no associations for the risk of oxidative damage to the muscle. Our findings may help to select young players with the most favorable genetic potential to succeed as soccer athletes.



MENEZES, W. C. F. Avaliação molecular dos polimorfismos genéticos na performance motora de atletas de futebol. 2019. 80 f. Dissertação (Mestrado em Assistência e Avaliação em Saúde) - Universidade Federal de Goiás, Goiânia, 2019.