Perspectivas em pesquisas sobre o gênero Campomanesia; estudos fitoquímicos e investigação de atividades biológicas em Campomanesia guazumifolia (Cambess) O. Berg - Myrtaceae
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2022-07-05
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Universidade Federal de Goiás
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Introduction: One of the challenges of public policies to encourage the use of herbal
medicines is the inclusion of more native species, such as those of the Campomanesia genus,
among the options for taking advantage of Brazilian biodiversity. Identifying research trends
on the genus and species may arouse the interest of researchers so that more native species,
such as Campomanesia guazumifolia (C.g) can be integrated into health systems where exotic
species predominate. Objectives: To evaluate the scientific production of the genus
Campomanesia and main species, especially C.g, in which the leaves of cultivated specimens
were the object of pharmacognostic studies, phytochemical profile, essential oil
characterization, antioxidant potential and biological activities. Methodology: Scientific
production on the genus and species was evaluated using scientometric tools using the Web of
Science database and the VOSviewer application. The experimental part consisted of
traditional pharmacognostic studies; the essential oil was characterized by means of gas
chromatography coupled to a mass spectrometer (GC-MS); the antioxidant potential was
evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method; larvicidal
activity by mortality of Aedes aegypti L3 larvae and the antimicrobial activity was tested by a
broth microdilution test. Results and discussion: Brazil leads research on gender and most
of them occurred after the implementation of herbal medicine policies. C.g was the species
with the highest proportional volume of publications in the last 5 years. The species presented
flavonoids, tannins, saponins and triterpenes in its composition. The major compound of the
essential oil (EO) was β-caryophyllene. The species showed good antioxidant (leaf extract and
powder), larvicidal (EO) and antimicrobial activity, mainly against Candida sp and Micrococcus
luteus strains. Conclusions: C. guazumifolia is a promising species for further research on
biological activities and other studies that can support the traditional use and also as a
phytomedicine.
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STECKELBERG, R. M. B. Perspectivas em pesquisas sobre o gênero Campomanesia; estudos fitoquímicos e investigação de atividades biológicas em Campomanesia guazumifolia (Cambess) O. Berg - Myrtaceae. 2022. 77 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, 2022.