AVALIAÇÃO DA ATIVIDADE ANTIINFLAMATÓRIA DA FRAÇÃO ALCALOÍDICA DO FRUTO DE Solanum lycocarpum A.St.-Hil. (LOBEIRA)
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2004-09-10
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Universidade Federal de Goiás
Resumo
Solanum lycocarpum A. St.-Hil., popularly known as lobeira (wolf-fruit), is easily
found in the Brazilian savanna. It is characterized as a bushy plant with average
height of about 5 meters (16 feet), fragile branches, featuring a nearly round berry
type of fruit, with diameter that ranges from 8 to 15 cm (3.1 to 5.9 inches),
yellowish green color even when ripe, fleshy and juicy pulp. The lobeira is used in
folk medicine for several therapeutic purposes such as bronchitis, worm diseases,
diabetes and ulcer. A study with ethanolic extract of fruit (EEF) of the lobeira
showed analgesic and antidermatogenic activity in the experimental samples of
acetic acid-induced abdominal writhing and ear edema. In the present work were
performed the morphoanatomic study of the fruit and the antiinflammatory
evaluation of the alkaloidic fraction (FA) acquired through the EEF. The
morphoanatomic analysis of the fruit pointed out the existence of elements that
allow its characterization, like the stellate trichomes, present in leaves of the same
species as well. The FA was obtained by acid extraction of the EEF, being defined
by thin-layer chromatography the presence of the glycoalkaloid solamargine, found
in other species of the Solanum genus. The antiinflamatory activity was estimated
in vivo through the ear edema method induced by the croton oil and by the
leukocyte migration in the peritonitis induced by carrageenin. It was estimated in
vitro the FA ability to restrain the phospholipase A2 action in snake poison. The
prior treatment of animals with FA in doses of 50 to 100mg/kg (s.c.) reduced the
ear edema formation, and in doses of 30 a 300mg/kg (s.c. and p.o.) decreased the
leukocyte migration. The experimental models in vivo demonstrated that the FA
displayed characteristic results of an antiinflamatory activity similar to the one
shown by the glycocorticoids. The results obtained with the FA could be outcome
of the glycoalkaloid presence and also indicate that the FA has the active
principles responsible for the biological activity verified in EEF. The FA has not
presented inhibitive activity of phospholipase A2 that could be detected by in vitro
method that was applied. It becomes necessary the purification of the
glycoalkaloid and the completion of specific trials aiming to confirm the
antiinflamatory action as well as the participating mechanisms.
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Citação
VIEIRA JÚNIOR, Geraldo. EVALUATION anti-inflammatory activity
FRACTION OF THE FRUIT OF ALKALOIDS
Wolf Apple A.St.-Hil. (Wolf). 2004. 59 f. Dissertação (Mestrado em Ciências Biolóicas) - Universidade Federal de Goiás, Goiânia, 2004.