Síntese de compostos heteroazóicos substituídos no solvente alternativo PEG 400
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2018-04-27
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Universidade Federal de Goiás
Resumo
The present work describes the development of a simple and efficient
methodology for the synthesis of 2-aminoheteroazoic compounds using the
solvent PEG 400 as an alternative to toxic and flammable organic solvents.
Several media and reactional conditions were compared. A series of substituted
2-aminothiazoic compounds was obtained in good yields (60 to 96%) by a 3 hour
reaction procedure using PEG 400 at room temperature and without the need for
additives or catalysts. A selenium analogue and a 2-imino-1,3-thiazoline were
also obtained by this method. The products were characterized by 1H and 13C
NMR and infrared spectroscopies and mass spectrometry. The method covers
some points of Green Chemistry, such as: safe synthesis, prevention in the
formation of residues or derivatives, development of products that do not harm
the environment, energy efficiency and accident prevention.
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FERREIRA, A. S. Síntese de compostos heteroazóicos substituídos no solvente alternativo PEG 400. 2018. 76 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Goiânia, 2018.